Optimal <i>Q</i> analysis for chromosome 10.

Optimal <i>Q</i> analysis for chromosome 10.

<p>(a) CDF for nestedness score for the real data (black thick line) and models associated with varying <i>Q</i>. In all CDFs, the extreme <i>N</i><sub><i>ij</i></sub> = ±1 values are excluded. (b) Kolmogorov-Smirnov distance, <i>D</i>...

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Bibliographic Details
Main Author:	Dolores Bernenko (16528426) (author)
Other Authors:	Sang Hoon Lee (211083) (author), Per Stenberg (36562) (author), Ludvig Lizana (2440240) (author)
Published:	2023
Subjects:	Biophysics Cell Biology Genetics Molecular Biology Cancer Biological Sciences not elsewhere classified similar sizes merge several insights derive regulate genetic processes hierarchical tree connecting community size spectrum chromosome capture methods chromosome &# 8217 actual folding hierarchy two competing mechanisms topologically associated domains ranged dna loops dna segment pairs nested community structure generalized louvain algorithm communities nest relative chromosomes &# 8217 like nested hierarchy c data assuming simple folding model perfect hierarchy often associated empirical data causal mechanisms measured dna dna repair dna regions dna interactions nested parts take advantage tads ). significant portion significant part scan seamlessly scale relationships results highlight resolution parameter phase separation paper aims pair compartments organizing principles models aiming model explains maps show loop extrusion g ., examining nesting essential components deep understanding chromosomes exhibit chromatin types c maps c experiments better understand b compartments appealing description allows us allow researchers active chromatin 3d structures 3d organization
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