Directionality of synovial gene expression + / − FVIII treatment 3 days after injury/bleed.

<p>DEGs of groups 1 (unique to rhFVIII – blue) and 2 (unique to mFcFVIII – gold) were selected and a scatter plot was generated with LogFC gene expression values (A). B and C lists all genes from groups 1 and 2 with LogFC values >4.0 or <-4.0 following saline treatment compared to baseli...

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Bibliographic Details
Main Author:	Bilgimol Chumappumkal Joseph (21387752) (author)
Other Authors:	Thomas C. Whisenant (15124111) (author), Esther J. Cooke (21387755) (author), Jenny Y. Zhou (6951371) (author), Nicca Falah (21387758) (author), Juan Andres De-Pablo Moreno (21387761) (author), Annette von Drygalski (615964) (author)
Published:	2025
Subjects:	Biochemistry Genetics Molecular Biology Physiology Immunology Biological Sciences not elsewhere classified synovial gene expression observations provide proof may modulate inflammation macrophage profiling indicated differential gene expression ko mice resulted synovial vascular remodeling also distinct differences deficient mice treated joint bleed control immune system pathways hemophilic synovium via d3 ), mfcfviii fc fusion protein target effects related deficient mice tissue remodeling temporal differences protein processing xlink "> target effects small proportion rnaseq data rna extraction reactome ). patellar puncture mfcfviii treatments life extension inflammatory regulation immunoglobulin used immune stimulation following groups exhibiting overlap deserving exploration cartilage health
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Directionality of synovial gene expression + / − FVIII treatment 3 days after injury/bleed.

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