Representative images of Hematoxylin-eosin (H&E) staining and retina thickness analysis among the three genotypes at 8 and 10 weeks of age.

<p>(A) H&E staining images of the retina. The dash lines indicate the boundary between IS (inner segment) and OS (outer segment). (B–E) Comparison of the RPE (retinal pigmented epithelium) and PTR (photoreceptor) thickness among the three genotypes at 8 and 10 weeks of age. The thickness o...

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Main Author:	Zhi-Jia Chen (3823780) (author)
Other Authors:	Chun-Yen Wu (11099653) (author), Fang-Yan Hsiao (21370274) (author), Jing-Chun Ma (21370277) (author), Gabriel Lai (11890931) (author), Han-Hsin Chang (55530) (author), David Pei-Cheng Lin (21370280) (author)
Published:	2025
Subjects:	Biophysics Medicine Cell Biology Genetics Neuroscience Developmental Biology Virology Biological Sciences not elsewhere classified retinal layer thickness retinal ganglion cells retinal degeneration characterized related retinal degeneration hyperphosphorylated tau proteins mutant mice retinas glial cell activation klotho protein function null mutation may null mutation leads th </ sup klotho </ null mutation function deprivation cell death mutant retina three genotypes study model study aimed retinopathy caused results revealed functional impairments functional impairment evident damage depth analysis degenerative pathogenesis alzheimer ’ accelerate aging
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Representative images of Hematoxylin-eosin (H&E) staining and retina thickness analysis among the three genotypes at 8 and 10 weeks of age.

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