Regulatory T cell frequency is reduced in pediatric patients during intestinal cellular rejection.

Regulatory T cell frequency is reduced in pediatric patients during intestinal cellular rejection.

<p><b>(A)</b> CD4<sup>+</sup>CD25<sup>high</sup>CD127<sup>-</sup> Treg frequency in blood of patients with and without graft rejection (n°/μL of blood; non-rejection n = 8, rejection n = 5). <b>(B)</b> Percentage of blood Tregs HLA-DR...

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Main Author:	Rodrigo Papa-Gobbi (20614489) (author)
Other Authors:	Pablo Stringa (10437683) (author), Maria Virginia Gentilini (20614492) (author), Ivana Ivanoff (20614495) (author), Mariana Machuca (20614498) (author), Nidia Monserrat Arreola (20614501) (author), Javier Serradilla (14555756) (author), Karla Estefanía-Fernández (20614504) (author), Paloma Talayero (14555765) (author), María Velayos (20614507) (author), Elena Sánchez—Zapardiel (20614510) (author), Gabriel Gondolesi (20614513) (author), Ane Andrés-Moreno (20614516) (author), Martin Rumbo (238945) (author), Francisco Hernández-Oliveros (14555762) (author)
Published:	2025
Subjects:	Cell Biology Neuroscience Pharmacology Biotechnology Immunology Marine Biology Cancer Mental Health Hematology Infectious Diseases heightened immunological load rejection rate surpasses graft remained free graft gene expression acute cellular rejection small bowel transplantation irreversible intestinal failure inflammatory mediators assessed treg number compared histological findings resembling sup >+</ sup receiving immunosuppression treatment experimental findings underscore graft treg expansion graft samples ). high </ sup treg frequency analyzed graft rejection histological findings treg frequency intestinal transplantation graft responses vs </ inflammatory genes high cd8 expansion within diminished number experimental model experimental allogenic mucosa samples human samples blood samples xlink "> significant reduction potential involvement peripheral tolerance mrna upregulation modulating host key players increased levels immunosuppressant treatment functional grafts flow cytometry facilitate blood enhance long diagnosed based curative option cell chimerism animals divided allograft outcomes 3 groups 2 mg 10 levels
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