Schematic illustration of the conserved functions of Rab23 in primary cilia.

Schematic illustration of the conserved functions of Rab23 in primary cilia.

<p><i><i>Rab23</i></i> exerts evolutionarily conserved and context-specific functions in maintaining morphologically intact and functional primary cilia. Specifically, in the absence of <i><i>Rab23</i></i>, severe perturbations in ciliogenesis we...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Wan Ying Leong (22075947) (author)
مؤلفون آخرون:	Wai Lam Tung (22075950) (author), Andrew O. M. Wilkie (17369632) (author), Catherine Hong Huan Hor (6539690) (author)
منشور في:	2025
الموضوعات:	Medicine Cell Biology Genetics Molecular Biology Neuroscience Developmental Biology Mental Health Hematology small gtpase known shortened cilia length remain poorly characterised phenotypical traits recapitulating patients ’ fibroblasts hedgehog signalling pathway hedgehog signaling pathway primary cilia formation primary cilia anomalies neural progenitor cells cerebellar granule cells type distinctive manner mouse embryonic fibroblasts thereby confirming cs present direct evidence div >< p vitro rab23 </ cs patient ipscs primary cilium epithelial cells mouse mutants findings present evidence validating dependent manner vivo </ rab23 </ cs patient cs bear cs ), zebrafish morphants specific function skeletal defects remains ambiguous profound reduction pathological manifestations observed specifically neurons differentiated neocortical neurons like phenotypes ipscs ), intellectual disability hippocampus neurons findings indicate exact relationship dependent activation conditional knockout clinical features ciliation frequency ciliary trafficking ciliary functions
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