Lipid Microcapsules Promoted Neural Stem Cell Survival in the Infarcted Area of Mice with Ischemic Stroke by Inducing Autophagy

Lipid Microcapsules Promoted Neural Stem Cell Survival in the Infarcted Area of Mice with Ischemic Stroke by Inducing Autophagy

Intracerebral transplantation of neural stem cells (NSCs) for ischemic stroke treatment has been demonstrated to be inefficient, with only <5% of delivered cells being retained. Microcapsules may be a good carrier for NSC delivery; however, the current microcapsules do not fully meet the demands...

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Bibliographic Details
Main Author: Rui Xu (158313) (author)
Other Authors: Chunmei Duan (9024560) (author), Zhaoyou Meng (322436) (author), Jian Zhao (219525) (author), Qian He (248656) (author), Qin Zhang (58638) (author), Changxiong Gong (13036263) (author), Jiacheng Huang (1639390) (author), Qi Xie (230608) (author), Qingwu Yang (53826) (author), Yang Bai (198601) (author)
Published: 2022
Subjects:
Medicine
Cell Biology
Neuroscience
Physiology
Pharmacology
Biotechnology
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
traumatic brain injury
enhanced autophagy flux
decreased brain edema
autophagy flux analysis
improved survival rate
neural stem cells
ldh release test
stem cell delivery
promote cell survival
study may provide
ischemic stroke treatment
support nscs delivery
good protective effect
cell survival
ischemic stroke
protective effect
nsc delivery
present study
good carrier
delivered cells
cck8 test
prosurvival effect
microcapsules may
step method
novel lipid
new method
mechanisms underlying
infarcted area
infarct volume
glucose deprivation
fully meet
flow cytometry
also performed
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