Evaluation of carbaribose modifications.

Potency, cytotoxicity, and persistence ratios in MT4-GFP cells and/or PBMCs for four compounds with carbaribose modifications. CH2, methylene; CC50, concentration of test compound required to reduce cell viability by 50%; CTG, CellTiter-Glo; GFP...

पूर्ण विवरण

में बचाया:

ग्रंथसूची विवरण
मुख्य लेखक:	Izzat T. Raheem (1503241) (author)
अन्य लेखक:	Vinay Girijavallabhan (2178380) (author), Kerry L. Fillgrove (1443550) (author), Shih Lin Goh (113726) (author), Carolyn Bahnck-Teets (2737183) (author), Qian Huang (127640) (author), Fangbiao Li (2127346) (author), Bang-Lin Wan (2224951) (author), Gregory T. O’Donnell (22126968) (author), Jonathan B. Patteson (22126971) (author), Maria E. Cilento (12563132) (author), Amrith Bennet (1503193) (author), Robert P. Hayes (9220508) (author), Srivanya Tummala (22126974) (author), Carolyn McHale (13551320) (author), Judyann Wiltsie (1622350) (author), Joan Ellis (2483083) (author), Ernest Asante-Appiah (3336858) (author), Daria J. Hazuda (263416) (author), Jeffrey Hale (22126977) (author), Jay A. Grobler (1779958) (author), Min Xu (15203) (author), Tracy L. Diamond (13551323) (author), Ming-Tain Lai (1534570) (author)
प्रकाशित:	2025
विषय:	Biophysics Biochemistry Cell Biology Pharmacology Cancer Science Policy Infectious Diseases Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified vivo studies led receptor binding assays potent antiretroviral agents potent antiretroviral activity good oral absorption following oral administration delayed chain termination approximately 48 h 95 &# 181 10 &# 956 attractive clinical candidate apparent plasma half novel deoxyadenosine analog tp inhibits translocation tp demonstrated favorable monthly oral hiv block hiv replication favorable preclinical pk div >< p inhibits reverse transcription reverse transcription &# 8805 intracellular half clinical trials reverse transcriptase novel long novel inhibitor tp exhibited hiv prophylaxis target profiles target activities systematic progression significantly longer respectively ). phosphorylated intracellularly parent compound nucleobase modifications moderate clearance iron footprinting inhibition allows duration dosing broad exploration active triphosphate acting nrtti 21 nm 114 enzyme 1 pre
टैग:	टैग जोड़ें कोई टैग नहीं, इस रिकॉर्ड को टैग करने वाले पहले व्यक्ति बनें!

Evaluation of carbaribose modifications.

समान संसाधन