Energy Resolved Mass Spectrometry Data from Surfaced Induced Dissociation Improves Prediction of Protein Complex Structure

Energy Resolved Mass Spectrometry Data from Surfaced Induced Dissociation Improves Prediction of Protein Complex Structure

Native Mass Spectrometry (nMS) is a versatile technique for elucidating protein structure. Surface-Induced Dissociation (SID) is an activation method in tandem MS predominantly employed for determining protein complex stoichiometry alongside information about interface strengths. SID-nMS data can be...

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Bibliographic Details
Main Author: Robert M. Bolz (20613729) (author)
Other Authors: Justin T. Seffernick (5030693) (author), Zachary C. Drake (20613732) (author), Sophie R. Harvey (6906119) (author), Vicki H. Wysocki (1235367) (author), Steffen Lindert (115057) (author)
Published: 2025
Subjects:
Biochemistry
Plant Biology
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Physical Sciences not elsewhere classified
Information Systems not elsewhere classified
20 protein complexes
single data point
test files provided
previous work demonstrated
elucidating protein structure
erms data provide
20 cases improving
experimental erms data
experimental data
erms data
20 cases
20 becoming
experimental modeling
versatile technique
usage tutorial
supporting information
showed improvement
rescored based
interface strengths
interface breakage
integrative computational
induced dissociation
highly accurate
generated models
full pattern
freely available
based rescoring
appearance energy
acceleration energies
5 å
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