Data Sheet 1_A novel TNFR2 agonist peptide for the expansion of CD4+Foxp3+ regulatory T cells.docx
<p>CD4<sup>+</sup>Foxp3<sup>+</sup> regulatory T cells (Tregs) are essential for maintaining immune tolerance, and selective expansion of Tregs via TNFR2 signaling represents a promising therapeutic approach for autoimmune and inflammatory diseases. Here, we report the...
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2025
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| _version_ | 1849927624241971200 |
|---|---|
| author | Ping Liao (5424887) |
| author2 | Zhonghao Chen (17011571) Yang Gao (18005) Yang Yang (45629) Yibo Chen (4634611) Jiamin Chen (388522) Yiru Wang (1686439) Chon-Kit Chou (587078) Shaoyi Zhang (9455358) Xin Chen (14149) |
| author2_role | author author author author author author author author author |
| author_facet | Ping Liao (5424887) Zhonghao Chen (17011571) Yang Gao (18005) Yang Yang (45629) Yibo Chen (4634611) Jiamin Chen (388522) Yiru Wang (1686439) Chon-Kit Chou (587078) Shaoyi Zhang (9455358) Xin Chen (14149) |
| author_role | author |
| dc.creator.none.fl_str_mv | Ping Liao (5424887) Zhonghao Chen (17011571) Yang Gao (18005) Yang Yang (45629) Yibo Chen (4634611) Jiamin Chen (388522) Yiru Wang (1686439) Chon-Kit Chou (587078) Shaoyi Zhang (9455358) Xin Chen (14149) |
| dc.date.none.fl_str_mv | 2025-11-26T05:15:22Z |
| dc.identifier.none.fl_str_mv | 10.3389/fimmu.2025.1696587.s003 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/dataset/Data_Sheet_1_A_novel_TNFR2_agonist_peptide_for_the_expansion_of_CD4_Foxp3_regulatory_T_cells_docx/30717758 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Genetic Immunology TNFR2 CD4+Foxp3+ regulatory T cells peptide immunosuppression inflammation |
| dc.title.none.fl_str_mv | Data Sheet 1_A novel TNFR2 agonist peptide for the expansion of CD4+Foxp3+ regulatory T cells.docx |
| dc.type.none.fl_str_mv | Dataset info:eu-repo/semantics/publishedVersion dataset |
| description | <p>CD4<sup>+</sup>Foxp3<sup>+</sup> regulatory T cells (Tregs) are essential for maintaining immune tolerance, and selective expansion of Tregs via TNFR2 signaling represents a promising therapeutic approach for autoimmune and inflammatory diseases. Here, we report the identification and characterization of UMR2-705, a novel TNFR2 agonist discovered through phage display screening. In vitro, peptide UMR2–705 selectively promoted Treg proliferation in both human peripheral blood mononuclear cells and murine CD4<sup>+</sup> T cell cultures without stimulating conventional CD4<sup>+</sup> effector or CD8<sup>+</sup> T cells. This effect was abrogated by the TNFR2-specific blocking antibody TR75-54.7, indicating its TNFR2 dependency. In vivo, administration of peptide UMR2–705 expanded Tregs in murine spleen and lymph nodes, attenuated LPS-induced systemic cytokine release (IL-6, TNF-α, IL-17A) in serum, and preserved immune homeostasis during systemic inflammation through TNFR2-dependent modulation of the regulatory compartment. Transcriptomic profiling revealed activation of TNFR2-associated signaling and upregulation of immune-regulatory pathways. These findings identify peptide UMR2–705 as a selective, peptide-based TNFR2 agonist with potent Treg-expanding and anti-inflammatory activities, supporting its potential as a therapeutic candidate for autoimmune and inflammatory disorders.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_f6fe56c2c0b501406c96add7811a8cdb |
| identifier_str_mv | 10.3389/fimmu.2025.1696587.s003 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30717758 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Data Sheet 1_A novel TNFR2 agonist peptide for the expansion of CD4+Foxp3+ regulatory T cells.docxPing Liao (5424887)Zhonghao Chen (17011571)Yang Gao (18005)Yang Yang (45629)Yibo Chen (4634611)Jiamin Chen (388522)Yiru Wang (1686439)Chon-Kit Chou (587078)Shaoyi Zhang (9455358)Xin Chen (14149)Genetic ImmunologyTNFR2CD4+Foxp3+ regulatory T cellspeptideimmunosuppressioninflammation<p>CD4<sup>+</sup>Foxp3<sup>+</sup> regulatory T cells (Tregs) are essential for maintaining immune tolerance, and selective expansion of Tregs via TNFR2 signaling represents a promising therapeutic approach for autoimmune and inflammatory diseases. Here, we report the identification and characterization of UMR2-705, a novel TNFR2 agonist discovered through phage display screening. In vitro, peptide UMR2–705 selectively promoted Treg proliferation in both human peripheral blood mononuclear cells and murine CD4<sup>+</sup> T cell cultures without stimulating conventional CD4<sup>+</sup> effector or CD8<sup>+</sup> T cells. This effect was abrogated by the TNFR2-specific blocking antibody TR75-54.7, indicating its TNFR2 dependency. In vivo, administration of peptide UMR2–705 expanded Tregs in murine spleen and lymph nodes, attenuated LPS-induced systemic cytokine release (IL-6, TNF-α, IL-17A) in serum, and preserved immune homeostasis during systemic inflammation through TNFR2-dependent modulation of the regulatory compartment. Transcriptomic profiling revealed activation of TNFR2-associated signaling and upregulation of immune-regulatory pathways. These findings identify peptide UMR2–705 as a selective, peptide-based TNFR2 agonist with potent Treg-expanding and anti-inflammatory activities, supporting its potential as a therapeutic candidate for autoimmune and inflammatory disorders.</p>2025-11-26T05:15:22ZDatasetinfo:eu-repo/semantics/publishedVersiondataset10.3389/fimmu.2025.1696587.s003https://figshare.com/articles/dataset/Data_Sheet_1_A_novel_TNFR2_agonist_peptide_for_the_expansion_of_CD4_Foxp3_regulatory_T_cells_docx/30717758CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/307177582025-11-26T05:15:22Z |
| spellingShingle | Data Sheet 1_A novel TNFR2 agonist peptide for the expansion of CD4+Foxp3+ regulatory T cells.docx Ping Liao (5424887) Genetic Immunology TNFR2 CD4+Foxp3+ regulatory T cells peptide immunosuppression inflammation |
| status_str | publishedVersion |
| title | Data Sheet 1_A novel TNFR2 agonist peptide for the expansion of CD4+Foxp3+ regulatory T cells.docx |
| title_full | Data Sheet 1_A novel TNFR2 agonist peptide for the expansion of CD4+Foxp3+ regulatory T cells.docx |
| title_fullStr | Data Sheet 1_A novel TNFR2 agonist peptide for the expansion of CD4+Foxp3+ regulatory T cells.docx |
| title_full_unstemmed | Data Sheet 1_A novel TNFR2 agonist peptide for the expansion of CD4+Foxp3+ regulatory T cells.docx |
| title_short | Data Sheet 1_A novel TNFR2 agonist peptide for the expansion of CD4+Foxp3+ regulatory T cells.docx |
| title_sort | Data Sheet 1_A novel TNFR2 agonist peptide for the expansion of CD4+Foxp3+ regulatory T cells.docx |
| topic | Genetic Immunology TNFR2 CD4+Foxp3+ regulatory T cells peptide immunosuppression inflammation |