Extracted ion chromatograms of Taspoglutide after 24 hours of incubation with DPP-4, using both algorithms.

Extracted ion chromatograms of Taspoglutide after 24 hours of incubation with DPP-4, using both algorithms.

<p>(Blue peak: represents the parent peptide compound, green peaks: first generation of metabolites, and brown peaks: second generation or higher).</p>

محفوظ في:
التفاصيل البيبلوغرافية
المؤلف الرئيسي: Paula Cifuentes (22050278) (author)
مؤلفون آخرون: Ismael Zamora (2385154) (author), Tatiana Radchenko (4559779) (author), Fabien Fontaine (75372) (author), Albert Garriga (22050281) (author), Luca Morettoni (4559788) (author), Jesper Kammersgaard Christensen (22050284) (author), Hans Helleberg (12980035) (author), Bridget A. Becker (2412181) (author)
منشور في: 2025
الموضوعات:
Biochemistry
Cancer
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
significant challenges persist
molecular weight range
enables clear localization
distinct fragmentation strategies
associated computational demands
700 &# 8211
automated liquid chromatography
instilling greater confidence
improved various stages
exploring metabolic susceptibility
enhanced visualization capabilities
small molecules metid
resolution mass spectrometry
data analysis applicable
advancing automated metid
macromolecules using high
level ), non
data analysis
automated software
visualization algorithm
various experimental
metabolic biotransformations
level ),
greater number
monoisotopic mass
abundant mass
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unnatural monomers
structural complexity
previous studies
peptides ).
metabolite structures
metabolite identification
macromolecules due
ionization conditions
hybrid mode
drug metabolism
drug development
degradation products
cyclic peptides
consistent detection
comprising linear
comprehensive understanding
compound procurement
commonly used
bond notation
accurate prediction
970 metabolites
7630 da
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