Extracted ion chromatograms of Taspoglutide after 24 hours of incubation with DPP-4, using both algorithms.

<p>(Blue peak: represents the parent peptide compound, green peaks: first generation of metabolites, and brown peaks: second generation or higher).</p>

محفوظ في:
التفاصيل البيبلوغرافية
المؤلف الرئيسي: Paula Cifuentes (22050278) (author)
مؤلفون آخرون: Ismael Zamora (2385154) (author), Tatiana Radchenko (4559779) (author), Fabien Fontaine (75372) (author), Albert Garriga (22050281) (author), Luca Morettoni (4559788) (author), Jesper Kammersgaard Christensen (22050284) (author), Hans Helleberg (12980035) (author), Bridget A. Becker (2412181) (author)
منشور في: 2025
الموضوعات:
الوسوم: إضافة وسم
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_version_ 1852017622390931456
author Paula Cifuentes (22050278)
author2 Ismael Zamora (2385154)
Tatiana Radchenko (4559779)
Fabien Fontaine (75372)
Albert Garriga (22050281)
Luca Morettoni (4559788)
Jesper Kammersgaard Christensen (22050284)
Hans Helleberg (12980035)
Bridget A. Becker (2412181)
author2_role author
author
author
author
author
author
author
author
author_facet Paula Cifuentes (22050278)
Ismael Zamora (2385154)
Tatiana Radchenko (4559779)
Fabien Fontaine (75372)
Albert Garriga (22050281)
Luca Morettoni (4559788)
Jesper Kammersgaard Christensen (22050284)
Hans Helleberg (12980035)
Bridget A. Becker (2412181)
author_role author
dc.creator.none.fl_str_mv Paula Cifuentes (22050278)
Ismael Zamora (2385154)
Tatiana Radchenko (4559779)
Fabien Fontaine (75372)
Albert Garriga (22050281)
Luca Morettoni (4559788)
Jesper Kammersgaard Christensen (22050284)
Hans Helleberg (12980035)
Bridget A. Becker (2412181)
dc.date.none.fl_str_mv 2025-08-13T20:42:30Z
dc.identifier.none.fl_str_mv 10.1371/journal.pone.0324668.g005
dc.relation.none.fl_str_mv https://figshare.com/articles/figure/Extracted_ion_chromatograms_of_Taspoglutide_after_24_hours_of_incubation_with_DPP-4_using_both_algorithms_/29905361
dc.rights.none.fl_str_mv CC BY 4.0
info:eu-repo/semantics/openAccess
dc.subject.none.fl_str_mv Biochemistry
Cancer
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
significant challenges persist
molecular weight range
enables clear localization
distinct fragmentation strategies
associated computational demands
700 &# 8211
automated liquid chromatography
instilling greater confidence
improved various stages
exploring metabolic susceptibility
enhanced visualization capabilities
small molecules metid
resolution mass spectrometry
data analysis applicable
advancing automated metid
macromolecules using high
level ), non
data analysis
automated software
visualization algorithm
various experimental
metabolic biotransformations
level ),
greater number
monoisotopic mass
abundant mass
xlink ">
unnatural monomers
structural complexity
previous studies
peptides ).
metabolite structures
metabolite identification
macromolecules due
ionization conditions
hybrid mode
drug metabolism
drug development
degradation products
cyclic peptides
consistent detection
comprising linear
comprehensive understanding
compound procurement
commonly used
bond notation
accurate prediction
970 metabolites
7630 da
dc.title.none.fl_str_mv Extracted ion chromatograms of Taspoglutide after 24 hours of incubation with DPP-4, using both algorithms.
dc.type.none.fl_str_mv Image
Figure
info:eu-repo/semantics/publishedVersion
image
description <p>(Blue peak: represents the parent peptide compound, green peaks: first generation of metabolites, and brown peaks: second generation or higher).</p>
eu_rights_str_mv openAccess
id Manara_f76d3bf2782edf2e6da7cd98d0d22900
identifier_str_mv 10.1371/journal.pone.0324668.g005
network_acronym_str Manara
network_name_str ManaraRepo
oai_identifier_str oai:figshare.com:article/29905361
publishDate 2025
repository.mail.fl_str_mv
repository.name.fl_str_mv
repository_id_str
rights_invalid_str_mv CC BY 4.0
spelling Extracted ion chromatograms of Taspoglutide after 24 hours of incubation with DPP-4, using both algorithms.Paula Cifuentes (22050278)Ismael Zamora (2385154)Tatiana Radchenko (4559779)Fabien Fontaine (75372)Albert Garriga (22050281)Luca Morettoni (4559788)Jesper Kammersgaard Christensen (22050284)Hans Helleberg (12980035)Bridget A. Becker (2412181)BiochemistryCancerBiological Sciences not elsewhere classifiedInformation Systems not elsewhere classifiedsignificant challenges persistmolecular weight rangeenables clear localizationdistinct fragmentation strategiesassociated computational demands700 &# 8211automated liquid chromatographyinstilling greater confidenceimproved various stagesexploring metabolic susceptibilityenhanced visualization capabilitiessmall molecules metidresolution mass spectrometrydata analysis applicableadvancing automated metidmacromolecules using highlevel ), nondata analysisautomated softwarevisualization algorithmvarious experimentalmetabolic biotransformationslevel ),greater numbermonoisotopic massabundant massxlink ">unnatural monomersstructural complexityprevious studiespeptides ).metabolite structuresmetabolite identificationmacromolecules dueionization conditionshybrid modedrug metabolismdrug developmentdegradation productscyclic peptidesconsistent detectioncomprising linearcomprehensive understandingcompound procurementcommonly usedbond notationaccurate prediction970 metabolites7630 da<p>(Blue peak: represents the parent peptide compound, green peaks: first generation of metabolites, and brown peaks: second generation or higher).</p>2025-08-13T20:42:30ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pone.0324668.g005https://figshare.com/articles/figure/Extracted_ion_chromatograms_of_Taspoglutide_after_24_hours_of_incubation_with_DPP-4_using_both_algorithms_/29905361CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/299053612025-08-13T20:42:30Z
spellingShingle Extracted ion chromatograms of Taspoglutide after 24 hours of incubation with DPP-4, using both algorithms.
Paula Cifuentes (22050278)
Biochemistry
Cancer
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
significant challenges persist
molecular weight range
enables clear localization
distinct fragmentation strategies
associated computational demands
700 &# 8211
automated liquid chromatography
instilling greater confidence
improved various stages
exploring metabolic susceptibility
enhanced visualization capabilities
small molecules metid
resolution mass spectrometry
data analysis applicable
advancing automated metid
macromolecules using high
level ), non
data analysis
automated software
visualization algorithm
various experimental
metabolic biotransformations
level ),
greater number
monoisotopic mass
abundant mass
xlink ">
unnatural monomers
structural complexity
previous studies
peptides ).
metabolite structures
metabolite identification
macromolecules due
ionization conditions
hybrid mode
drug metabolism
drug development
degradation products
cyclic peptides
consistent detection
comprising linear
comprehensive understanding
compound procurement
commonly used
bond notation
accurate prediction
970 metabolites
7630 da
status_str publishedVersion
title Extracted ion chromatograms of Taspoglutide after 24 hours of incubation with DPP-4, using both algorithms.
title_full Extracted ion chromatograms of Taspoglutide after 24 hours of incubation with DPP-4, using both algorithms.
title_fullStr Extracted ion chromatograms of Taspoglutide after 24 hours of incubation with DPP-4, using both algorithms.
title_full_unstemmed Extracted ion chromatograms of Taspoglutide after 24 hours of incubation with DPP-4, using both algorithms.
title_short Extracted ion chromatograms of Taspoglutide after 24 hours of incubation with DPP-4, using both algorithms.
title_sort Extracted ion chromatograms of Taspoglutide after 24 hours of incubation with DPP-4, using both algorithms.
topic Biochemistry
Cancer
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
significant challenges persist
molecular weight range
enables clear localization
distinct fragmentation strategies
associated computational demands
700 &# 8211
automated liquid chromatography
instilling greater confidence
improved various stages
exploring metabolic susceptibility
enhanced visualization capabilities
small molecules metid
resolution mass spectrometry
data analysis applicable
advancing automated metid
macromolecules using high
level ), non
data analysis
automated software
visualization algorithm
various experimental
metabolic biotransformations
level ),
greater number
monoisotopic mass
abundant mass
xlink ">
unnatural monomers
structural complexity
previous studies
peptides ).
metabolite structures
metabolite identification
macromolecules due
ionization conditions
hybrid mode
drug metabolism
drug development
degradation products
cyclic peptides
consistent detection
comprising linear
comprehensive understanding
compound procurement
commonly used
bond notation
accurate prediction
970 metabolites
7630 da