Figure 1 from Imaging Glioblastoma Response to Radiotherapy Using <sup>2</sup>H Magnetic Resonance Spectroscopy Measurements of Fumarate Metabolism
<p><sup>2</sup>H NMR measurements of labeled fumarate, malate, and water in cell culture medium. <b>A</b> and <b>B,</b> Representative <sup>2</sup>H NMR spectra of medium from untreated S2 cells (<b>A</b>) and from cells 24 hours afte...
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2025
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| _version_ | 1849927639753555968 |
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| author | Friederike Hesse (14958870) |
| author2 | Alan J. Wright (14931815) Vencel Somai (14958873) Flaviu Bulat (14958876) Felix Kreis (14931818) Kevin M. Brindle (9752021) |
| author2_role | author author author author author |
| author_facet | Friederike Hesse (14958870) Alan J. Wright (14931815) Vencel Somai (14958873) Flaviu Bulat (14958876) Felix Kreis (14931818) Kevin M. Brindle (9752021) |
| author_role | author |
| dc.creator.none.fl_str_mv | Friederike Hesse (14958870) Alan J. Wright (14931815) Vencel Somai (14958873) Flaviu Bulat (14958876) Felix Kreis (14931818) Kevin M. Brindle (9752021) |
| dc.date.none.fl_str_mv | 2025-11-24T22:42:24Z |
| dc.identifier.none.fl_str_mv | 10.1158/0008-5472.30699287 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Figure_1_from_Imaging_Glioblastoma_Response_to_Radiotherapy_Using_sup_2_sup_H_Magnetic_Resonance_Spectroscopy_Measurements_of_Fumarate_Metabolism/30699287 |
| dc.rights.none.fl_str_mv | CC BY info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Cancer Methods and Technology Imaging Imaging probes Magnetic resonance imaging (MRI) Small animal imaging |
| dc.title.none.fl_str_mv | Figure 1 from Imaging Glioblastoma Response to Radiotherapy Using <sup>2</sup>H Magnetic Resonance Spectroscopy Measurements of Fumarate Metabolism |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p><sup>2</sup>H NMR measurements of labeled fumarate, malate, and water in cell culture medium. <b>A</b> and <b>B,</b> Representative <sup>2</sup>H NMR spectra of medium from untreated S2 cells (<b>A</b>) and from cells 24 hours after the last chemoradiotherapy treatment (5 Gy per fraction, 15 Gy in total, and 50 μmol/L temozolomide; <b>B</b>), 2 hours after the addition of 5 mmol/L [2,3-<sup>2</sup>H<sub>2</sub>]fumarate. Deuterated fumarate, malate, and water concentrations in medium from untreated S2 (<b>C</b>), A11 (<b>F</b>), and U87 (<b>I</b>) cells and treated S2 (<b>D</b>), A11 (<b>G</b>), and U87 (<b>J</b>) cells at the indicated times after addition of 5 mmol/L [2,3–<sup>2</sup>H<sub>2</sub>]fumarate. Rates of labeled malate production in untreated and treated S2 (***, <i>P</i> = 0.0028; <b>E</b>), A11 (*, <i>P</i> = 0.0105; <b>H</b>), and U87 (**, <i>P</i> = 0.0075; <b>K</b>) cell suspensions (mean ± SD; <i>n</i> = 3 biological replicates). Cell viability was measured in control (<b>L</b>) and chemoradiotherapy (<b>M</b>)-treated S2, A11, and U87 cells at the indicated time points following collection of the media samples.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_f8eadefa2901d602e8e3d7d79476308a |
| identifier_str_mv | 10.1158/0008-5472.30699287 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30699287 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY |
| spelling | Figure 1 from Imaging Glioblastoma Response to Radiotherapy Using <sup>2</sup>H Magnetic Resonance Spectroscopy Measurements of Fumarate MetabolismFriederike Hesse (14958870)Alan J. Wright (14931815)Vencel Somai (14958873)Flaviu Bulat (14958876)Felix Kreis (14931818)Kevin M. Brindle (9752021)CancerMethods and TechnologyImagingImaging probesMagnetic resonance imaging (MRI)Small animal imaging<p><sup>2</sup>H NMR measurements of labeled fumarate, malate, and water in cell culture medium. <b>A</b> and <b>B,</b> Representative <sup>2</sup>H NMR spectra of medium from untreated S2 cells (<b>A</b>) and from cells 24 hours after the last chemoradiotherapy treatment (5 Gy per fraction, 15 Gy in total, and 50 μmol/L temozolomide; <b>B</b>), 2 hours after the addition of 5 mmol/L [2,3-<sup>2</sup>H<sub>2</sub>]fumarate. Deuterated fumarate, malate, and water concentrations in medium from untreated S2 (<b>C</b>), A11 (<b>F</b>), and U87 (<b>I</b>) cells and treated S2 (<b>D</b>), A11 (<b>G</b>), and U87 (<b>J</b>) cells at the indicated times after addition of 5 mmol/L [2,3–<sup>2</sup>H<sub>2</sub>]fumarate. Rates of labeled malate production in untreated and treated S2 (***, <i>P</i> = 0.0028; <b>E</b>), A11 (*, <i>P</i> = 0.0105; <b>H</b>), and U87 (**, <i>P</i> = 0.0075; <b>K</b>) cell suspensions (mean ± SD; <i>n</i> = 3 biological replicates). Cell viability was measured in control (<b>L</b>) and chemoradiotherapy (<b>M</b>)-treated S2, A11, and U87 cells at the indicated time points following collection of the media samples.</p>2025-11-24T22:42:24ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1158/0008-5472.30699287https://figshare.com/articles/figure/Figure_1_from_Imaging_Glioblastoma_Response_to_Radiotherapy_Using_sup_2_sup_H_Magnetic_Resonance_Spectroscopy_Measurements_of_Fumarate_Metabolism/30699287CC BYinfo:eu-repo/semantics/openAccessoai:figshare.com:article/306992872025-11-24T22:42:24Z |
| spellingShingle | Figure 1 from Imaging Glioblastoma Response to Radiotherapy Using <sup>2</sup>H Magnetic Resonance Spectroscopy Measurements of Fumarate Metabolism Friederike Hesse (14958870) Cancer Methods and Technology Imaging Imaging probes Magnetic resonance imaging (MRI) Small animal imaging |
| status_str | publishedVersion |
| title | Figure 1 from Imaging Glioblastoma Response to Radiotherapy Using <sup>2</sup>H Magnetic Resonance Spectroscopy Measurements of Fumarate Metabolism |
| title_full | Figure 1 from Imaging Glioblastoma Response to Radiotherapy Using <sup>2</sup>H Magnetic Resonance Spectroscopy Measurements of Fumarate Metabolism |
| title_fullStr | Figure 1 from Imaging Glioblastoma Response to Radiotherapy Using <sup>2</sup>H Magnetic Resonance Spectroscopy Measurements of Fumarate Metabolism |
| title_full_unstemmed | Figure 1 from Imaging Glioblastoma Response to Radiotherapy Using <sup>2</sup>H Magnetic Resonance Spectroscopy Measurements of Fumarate Metabolism |
| title_short | Figure 1 from Imaging Glioblastoma Response to Radiotherapy Using <sup>2</sup>H Magnetic Resonance Spectroscopy Measurements of Fumarate Metabolism |
| title_sort | Figure 1 from Imaging Glioblastoma Response to Radiotherapy Using <sup>2</sup>H Magnetic Resonance Spectroscopy Measurements of Fumarate Metabolism |
| topic | Cancer Methods and Technology Imaging Imaging probes Magnetic resonance imaging (MRI) Small animal imaging |