Wisdom of Crowds for Supporting the Safety Evaluation of Nanomaterials

Wisdom of Crowds for Supporting the Safety Evaluation of Nanomaterials

The development of new approach methodologies (NAMs) to replace current <i>in vivo</i> testing for the safety assessment of engineered nanomaterials (ENMs) is hindered by the scarcity of validated experimental data for many ENMs. We introduce a framework to address this challenge by harn...

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Autore principale: Laura Aliisa Saarimäki (21737050) (author)
Altri autori: Michele Fratello (3530534) (author), Giusy del Giudice (13190092) (author), Emanuele Di Lieto (21194333) (author), Antreas Afantitis (2100013) (author), Harri Alenius (31952) (author), Eliodoro Chiavazzo (1376766) (author), Mary Gulumian (668890) (author), Piia Karisola (266792) (author), Iseult Lynch (202013) (author), Giulia Mancardi (2627299) (author), Georgia Melagraki (2100010) (author), Paolo Netti (4165993) (author), Anastasios G. Papadiamantis (9769104) (author), Willie Peijnenburg (3126480) (author), Hélder A Santos (21737053) (author), Tommaso Serchi (2467720) (author), Mohammad-Ali Shahbazi (1467862) (author), Tobias Stoeger (72712) (author), Eugenia Valsami-Jones (453999) (author), Paola Vivo (1432777) (author), Ivana Vinković Vrček (10226149) (author), Ulla Vogel (21241) (author), Peter Wick (435597) (author), David A. Winkler (220462) (author), Angela Serra (3530537) (author), Dario Greco (79166) (author)
Pubblicazione: 2025
Soggetti:
Medicine
Genetics
Ecology
Science Policy
Infectious Diseases
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
underlying toxicity mechanisms
rapidly evolving landscape
providing robust estimations
oxidative stress emerge
new approach methodologies
metal ion homeostasis
gene expression profiles
integrating expert knowledge
integrating expert insights
fill data gaps
validated experimental data
scalable safety assessment
nanosafety computational models
experimental data
safety assessment
expert opinion
computational modeling
safety evaluation
woc ).
vivo </
thereby enhancing
study showcases
replace current
predictive power
multiple complementary
investigation reveals
genes associated
enm descriptors
concern levels
collective expertise
building upon
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