APP deficiency impairs the normal firing patterns of PCs.

APP deficiency impairs the normal firing patterns of PCs.

<p><b>(A)</b> Representative spontaneous firing patterns recorded in PCs of wild-type (<i>App</i><sup>+/+</sup>) mice. Pie charts in the right panel showing the percentage of PC firing pattern. <i>App</i><sup>+/+</sup>, <i>n<...

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Dettagli Bibliografici
Autore principale:	Miao-Jin Ji (22676552) (author)
Altri autori:	Tong-Xuan Wu (22676555) (author), Chenhao Tian (10801643) (author), Xiang Cao (298023) (author), Ruyuan Wei (22676558) (author), Yin-Yin Yang (301866) (author), Xinran Meng (11537536) (author), Huanyao Tang (22676561) (author), Tiantao Cui (22676564) (author), Jiao Yang (623531) (author), Xin Tang (134573) (author), Chao Liu (43092) (author)
Pubblicazione:	2025
Soggetti:	Biochemistry Cell Biology Molecular Biology Neuroscience Physiology Developmental Biology Infectious Diseases mediated sodium currents deep cerebellar nucleus aberrant firing patterns specific app reconstitution cerebellar motor control app deficiency leads electrophysiological analysis revealed 6 channel activity motor performance motor function motor deficits app selectively purkinje cells marked reduction impaired locomotion findings reveal exogenous expression essential role dcn ). conditional knockdown behavioral deficits
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