H2AK119ub is developmentally enriched at H3K27ac-positive enhancers in the late cerebellum.

<p>(A) Heatmaps depicting normalized H2AK119ub CUT&RUN data centered around H3K27ac peak summits identified by MACS2 narrow in the late cerebellum. (B) Heatmaps depicting normalized H2AK119ub CUT&RUN data centered around active enhancers (intersection of SEACR-defined H3K27ac peaks and...

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Main Author:	Aditya Parmar (22331873) (author)
Other Authors:	Anjali Srinivasan (22331876) (author), Lena Krockenberger (22331879) (author), Abijith Augustine (22331882) (author), Owin Gong (22331885) (author), Addison C. Bullard (22331888) (author), Riya Kalra (22331891) (author), Leya Ledvin (22331894) (author), Dylan Pilz (21246648) (author), Jonathan Tawil (22331897) (author), Challana E. Tea (22331900) (author), Kelly C. Wang (22331903) (author), Olivia Urso (22331906) (author), Larissa M. Kaube (22331909) (author), Ying Sun (23237) (author), Roman Sasik (193092) (author), Kyle J. Gaulton (7703387) (author), Kathleen M. Fisch (4730523) (author), Cole J. Ferguson (22331912) (author)
Published:	2025
Subjects:	Biochemistry Cell Biology Genetics Molecular Biology Neuroscience Developmental Biology Cancer Science Policy two postnatal timepoints two marks colocalized heterochromatic zones dominated expressed gene bodies dependent histone modifications data lead us chemically modifying histones 3 months ). dynamic chromatin state compact chromatin structure regulatory elements tended prc2 product h3k27me3 dynamically regulate euchromatin normal prc activities h2ak119ub appears within promoters reduced transcription associated modifications h3k4me3 regulatory elements chromatin signature map prc h2ak119ub within used cut repress transcription remaining uncorrelated neurodevelopmental disorders mouse cerebellum lysine 119 h2ak119ub ), epigenetic dysregulation day 12 corresponding mrnas cerebellum matures cerebellum compared broadly speaking also gain 2 independently
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H2AK119ub is developmentally enriched at H3K27ac-positive enhancers in the late cerebellum.

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