Establishment of a senescence-related graft survival prognostic model.
<p><b>A.</b> Univariable Cox regression analysis screening prognostic SRGs. <b>B.</b> Ten-fold cross-validation selecting λ in LASSO model. <b>C.</b> LASSO coefficient profiles of 12 pSRGs. The optimal λ = 4 was selected. <b>D.</b> Coefficients o...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , |
| منشور في: |
2024
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| الموضوعات: | |
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| _version_ | 1852024869487640576 |
|---|---|
| author | Xihao Shen (20347942) |
| author2 | Jiyue Wu (3814717) Feilong Zhang (420300) Qing Bi (3864823) Zejia Sun (10031646) Wei Wang (17594) |
| author2_role | author author author author author |
| author_facet | Xihao Shen (20347942) Jiyue Wu (3814717) Feilong Zhang (420300) Qing Bi (3864823) Zejia Sun (10031646) Wei Wang (17594) |
| author_role | author |
| dc.creator.none.fl_str_mv | Xihao Shen (20347942) Jiyue Wu (3814717) Feilong Zhang (420300) Qing Bi (3864823) Zejia Sun (10031646) Wei Wang (17594) |
| dc.date.none.fl_str_mv | 2024-11-27T18:29:46Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pone.0312272.g008 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Establishment_of_a_senescence-related_graft_survival_prognostic_model_/27920737 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Cell Biology Genetics Molecular Biology Neuroscience Biotechnology Developmental Biology Marine Biology Cancer Virology Computational Biology weighted gene co two clusters underscored multiple established databases machine learning algorithms integrative machine learning gene expression omnibus demographic shift towards consensus clustering algorithm b >(</ b aged donor kidneys term graft outcomes expression network analysis differential expression analysis comprehensive analysis underscores worse graft survival reduced graft survival predicting graft survival two rejection clusters rejection remains elusive optimal acute rejection delayed graft function ktx rejection poses ktx rejection occurrence identify predictive srgs invasive diagnostic model kidney transplant rejection graft survival ktx rejection kidney graft diagnostic model kidney rejection gsva analysis cluster analysis allograft function rejection samples diagnosing rejection prognostic model kidney transplantation xlink "> wgcna ), significant threat related genes provided microarray positive correlation level landscape ischemic damage detailed cellular conducted using conclusions drawn cluster c1 c2 ). |
| dc.title.none.fl_str_mv | Establishment of a senescence-related graft survival prognostic model. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p><b>A.</b> Univariable Cox regression analysis screening prognostic SRGs. <b>B.</b> Ten-fold cross-validation selecting λ in LASSO model. <b>C.</b> LASSO coefficient profiles of 12 pSRGs. The optimal λ = 4 was selected. <b>D.</b> Coefficients of the candidate SRGs. <b>E-G.</b> Time-dependent ROC analysis in the training group (<b>E</b>), the testing group(<b>F</b>) and all(<b>G</b>).</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_f9f3fd94a7d8e71d835b0bdd3ec552b8 |
| identifier_str_mv | 10.1371/journal.pone.0312272.g008 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/27920737 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Establishment of a senescence-related graft survival prognostic model.Xihao Shen (20347942)Jiyue Wu (3814717)Feilong Zhang (420300)Qing Bi (3864823)Zejia Sun (10031646)Wei Wang (17594)Cell BiologyGeneticsMolecular BiologyNeuroscienceBiotechnologyDevelopmental BiologyMarine BiologyCancerVirologyComputational Biologyweighted gene cotwo clusters underscoredmultiple established databasesmachine learning algorithmsintegrative machine learninggene expression omnibusdemographic shift towardsconsensus clustering algorithmb >(</ baged donor kidneysterm graft outcomesexpression network analysisdifferential expression analysiscomprehensive analysis underscoresworse graft survivalreduced graft survivalpredicting graft survivaltwo rejection clustersrejection remains elusiveoptimal acute rejectiondelayed graft functionktx rejection posesktx rejection occurrenceidentify predictive srgsinvasive diagnostic modelkidney transplant rejectiongraft survivalktx rejectionkidney graftdiagnostic modelkidney rejectiongsva analysiscluster analysisallograft functionrejection samplesdiagnosing rejectionprognostic modelkidney transplantationxlink ">wgcna ),significant threatrelated genesprovided microarraypositive correlationlevel landscapeischemic damagedetailed cellularconducted usingconclusions drawncluster c1c2 ).<p><b>A.</b> Univariable Cox regression analysis screening prognostic SRGs. <b>B.</b> Ten-fold cross-validation selecting λ in LASSO model. <b>C.</b> LASSO coefficient profiles of 12 pSRGs. The optimal λ = 4 was selected. <b>D.</b> Coefficients of the candidate SRGs. <b>E-G.</b> Time-dependent ROC analysis in the training group (<b>E</b>), the testing group(<b>F</b>) and all(<b>G</b>).</p>2024-11-27T18:29:46ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pone.0312272.g008https://figshare.com/articles/figure/Establishment_of_a_senescence-related_graft_survival_prognostic_model_/27920737CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/279207372024-11-27T18:29:46Z |
| spellingShingle | Establishment of a senescence-related graft survival prognostic model. Xihao Shen (20347942) Cell Biology Genetics Molecular Biology Neuroscience Biotechnology Developmental Biology Marine Biology Cancer Virology Computational Biology weighted gene co two clusters underscored multiple established databases machine learning algorithms integrative machine learning gene expression omnibus demographic shift towards consensus clustering algorithm b >(</ b aged donor kidneys term graft outcomes expression network analysis differential expression analysis comprehensive analysis underscores worse graft survival reduced graft survival predicting graft survival two rejection clusters rejection remains elusive optimal acute rejection delayed graft function ktx rejection poses ktx rejection occurrence identify predictive srgs invasive diagnostic model kidney transplant rejection graft survival ktx rejection kidney graft diagnostic model kidney rejection gsva analysis cluster analysis allograft function rejection samples diagnosing rejection prognostic model kidney transplantation xlink "> wgcna ), significant threat related genes provided microarray positive correlation level landscape ischemic damage detailed cellular conducted using conclusions drawn cluster c1 c2 ). |
| status_str | publishedVersion |
| title | Establishment of a senescence-related graft survival prognostic model. |
| title_full | Establishment of a senescence-related graft survival prognostic model. |
| title_fullStr | Establishment of a senescence-related graft survival prognostic model. |
| title_full_unstemmed | Establishment of a senescence-related graft survival prognostic model. |
| title_short | Establishment of a senescence-related graft survival prognostic model. |
| title_sort | Establishment of a senescence-related graft survival prognostic model. |
| topic | Cell Biology Genetics Molecular Biology Neuroscience Biotechnology Developmental Biology Marine Biology Cancer Virology Computational Biology weighted gene co two clusters underscored multiple established databases machine learning algorithms integrative machine learning gene expression omnibus demographic shift towards consensus clustering algorithm b >(</ b aged donor kidneys term graft outcomes expression network analysis differential expression analysis comprehensive analysis underscores worse graft survival reduced graft survival predicting graft survival two rejection clusters rejection remains elusive optimal acute rejection delayed graft function ktx rejection poses ktx rejection occurrence identify predictive srgs invasive diagnostic model kidney transplant rejection graft survival ktx rejection kidney graft diagnostic model kidney rejection gsva analysis cluster analysis allograft function rejection samples diagnosing rejection prognostic model kidney transplantation xlink "> wgcna ), significant threat related genes provided microarray positive correlation level landscape ischemic damage detailed cellular conducted using conclusions drawn cluster c1 c2 ). |