Endoscopic Delivery of a Double-Umbrella-Shaped Hydrogel Occluder with Instant Mechanical Interlock and Robust Wet Adhesion for Gastric Perforation Repair

Achieving robust adhesion of bioadhesives on wet tissues to block gastric perforation remains a challenge due to the gradually deteriorated adhesive-tissue interactions by interfacial acidity and multienzyme gastric fluids, thus accompanying failure shedding and life-threatening risks. Here, we repo...

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Bibliographic Details
Main Author:	Haiyang Li (1557451) (author)
Other Authors:	Ningli Chai (821840) (author), Yanyu Yang (1462408) (author), Zhenyu Liu (179092) (author), Zhengyuan Liu (11868933) (author), Xuemiao Liu (21022164) (author), Shuang Liu (8449) (author), Lizhou Zhu (21022167) (author), Haoqi Zhai (21022170) (author), Wengang Zhang (3594995) (author), Chen Du (3439355) (author), Xing Wang (154377) (author), Longsong Li (9085624) (author), Enqiang Linghu (568118) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Medicine Molecular Biology Pharmacology Biotechnology Cancer Computational Biology Space Science Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Physical Sciences not elsewhere classified various topologies according reducible disulfide cross mechanically dynamic environments instant mechanical interlock gradually deteriorated adhesive g ., h fast mechanical interlocking endogenous growth factors deliverable hydrogel occluder multienzyme gastric fluids shaped hydrogel occluder large gastric perforations validate eho ’ interfacial physiochemical interactions robust wet adhesion gastric acid tissue interactions shaped endoscopy interfacial acidity gastrointestinal perforations wet tissues vivo </ tolerant acidic thus offering threatening risks therapeutic efficacy promising alternative porcine stomach molding technique improved retention healing process gradual self facilely tailored endoscopic delivery digestive pepsin clinical repair challenge due caffeic acid biodegradable eho application scenarios
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Endoscopic Delivery of a Double-Umbrella-Shaped Hydrogel Occluder with Instant Mechanical Interlock and Robust Wet Adhesion for Gastric Perforation Repair

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