The results of mitochondrial dysfunction related proteins with potential therapeutic drug molecular docking.
<p><b>(A)</b> DLAT docking results with NADH, Radicicol, and Dihydrolipoic Acid. <b>(B)</b> DLD docking results with NADH, Flavin adenine dinucleotide, and Glycine. <b>(C)</b> FDX1 docking results with Mitotane. <b>(D)</b> PDHA1 docking results w...
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2025
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| _version_ | 1852018389859434496 |
|---|---|
| author | Tingting Liu (267387) |
| author2 | Jingwen Li (314020) Junshi Zhang (9404552) Jianshe Wei (18435783) |
| author2_role | author author author |
| author_facet | Tingting Liu (267387) Jingwen Li (314020) Junshi Zhang (9404552) Jianshe Wei (18435783) |
| author_role | author |
| dc.creator.none.fl_str_mv | Tingting Liu (267387) Jingwen Li (314020) Junshi Zhang (9404552) Jianshe Wei (18435783) |
| dc.date.none.fl_str_mv | 2025-07-17T17:44:48Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pone.0327550.g012 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/The_results_of_mitochondrial_dysfunction_related_proteins_with_potential_therapeutic_drug_molecular_docking_/29593655 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biochemistry Cell Biology Genetics Molecular Biology Biological Sciences not elsewhere classified various analytical methods transmission electron microscopy process potentially leading potential therapeutic drugs parkinson &# 8217 neurodegenerative condition characterized modulating copper metabolism mirna network highlighted induced mouse model 31 distinct modules expression network analysis differential expression analysis potential hub genes identify module genes uncovered mitochondrial alterations potential pd treatments differentially expressed cuproptosis differential gene expression early pd diagnosis disease </ p related genes associated related genes protein analysis analysis led related pathways mitochondrial function mitochondrial dysfunction pd prevention pd ), thereby enhancing sy5y cells study concluded remaining five motor deficits kyoto encyclopedia intersecting degs internal training including nadh geo database gene ontology external validation enrichment analyses dopamine neurons designating one degs ). additional scrutiny 9 ), |
| dc.title.none.fl_str_mv | The results of mitochondrial dysfunction related proteins with potential therapeutic drug molecular docking. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p><b>(A)</b> DLAT docking results with NADH, Radicicol, and Dihydrolipoic Acid. <b>(B)</b> DLD docking results with NADH, Flavin adenine dinucleotide, and Glycine. <b>(C)</b> FDX1 docking results with Mitotane. <b>(D)</b> PDHA1 docking results with NADH. <b>(E)</b> PDHB docking results with NADH and Pyruvic acid. <b>(F)</b> GLRX5 docking results with DB08698 and DB08272. <b>(G)</b> HSPA1A docking results with Phenethyl Isothiocyanate. <b>(H)</b> LIAS docking results with Lipoic acid.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_fb31c1edd8ea46af040c61e2aed64811 |
| identifier_str_mv | 10.1371/journal.pone.0327550.g012 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/29593655 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | The results of mitochondrial dysfunction related proteins with potential therapeutic drug molecular docking.Tingting Liu (267387)Jingwen Li (314020)Junshi Zhang (9404552)Jianshe Wei (18435783)BiochemistryCell BiologyGeneticsMolecular BiologyBiological Sciences not elsewhere classifiedvarious analytical methodstransmission electron microscopyprocess potentially leadingpotential therapeutic drugsparkinson &# 8217neurodegenerative condition characterizedmodulating copper metabolismmirna network highlightedinduced mouse model31 distinct modulesexpression network analysisdifferential expression analysispotential hub genesidentify module genesuncovered mitochondrial alterationspotential pd treatmentsdifferentially expressed cuproptosisdifferential gene expressionearly pd diagnosisdisease </ prelated genes associatedrelated genesprotein analysisanalysis ledrelated pathwaysmitochondrial functionmitochondrial dysfunctionpd preventionpd ),thereby enhancingsy5y cellsstudy concludedremaining fivemotor deficitskyoto encyclopediaintersecting degsinternal trainingincluding nadhgeo databasegene ontologyexternal validationenrichment analysesdopamine neuronsdesignating onedegs ).additional scrutiny9 ),<p><b>(A)</b> DLAT docking results with NADH, Radicicol, and Dihydrolipoic Acid. <b>(B)</b> DLD docking results with NADH, Flavin adenine dinucleotide, and Glycine. <b>(C)</b> FDX1 docking results with Mitotane. <b>(D)</b> PDHA1 docking results with NADH. <b>(E)</b> PDHB docking results with NADH and Pyruvic acid. <b>(F)</b> GLRX5 docking results with DB08698 and DB08272. <b>(G)</b> HSPA1A docking results with Phenethyl Isothiocyanate. <b>(H)</b> LIAS docking results with Lipoic acid.</p>2025-07-17T17:44:48ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pone.0327550.g012https://figshare.com/articles/figure/The_results_of_mitochondrial_dysfunction_related_proteins_with_potential_therapeutic_drug_molecular_docking_/29593655CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/295936552025-07-17T17:44:48Z |
| spellingShingle | The results of mitochondrial dysfunction related proteins with potential therapeutic drug molecular docking. Tingting Liu (267387) Biochemistry Cell Biology Genetics Molecular Biology Biological Sciences not elsewhere classified various analytical methods transmission electron microscopy process potentially leading potential therapeutic drugs parkinson &# 8217 neurodegenerative condition characterized modulating copper metabolism mirna network highlighted induced mouse model 31 distinct modules expression network analysis differential expression analysis potential hub genes identify module genes uncovered mitochondrial alterations potential pd treatments differentially expressed cuproptosis differential gene expression early pd diagnosis disease </ p related genes associated related genes protein analysis analysis led related pathways mitochondrial function mitochondrial dysfunction pd prevention pd ), thereby enhancing sy5y cells study concluded remaining five motor deficits kyoto encyclopedia intersecting degs internal training including nadh geo database gene ontology external validation enrichment analyses dopamine neurons designating one degs ). additional scrutiny 9 ), |
| status_str | publishedVersion |
| title | The results of mitochondrial dysfunction related proteins with potential therapeutic drug molecular docking. |
| title_full | The results of mitochondrial dysfunction related proteins with potential therapeutic drug molecular docking. |
| title_fullStr | The results of mitochondrial dysfunction related proteins with potential therapeutic drug molecular docking. |
| title_full_unstemmed | The results of mitochondrial dysfunction related proteins with potential therapeutic drug molecular docking. |
| title_short | The results of mitochondrial dysfunction related proteins with potential therapeutic drug molecular docking. |
| title_sort | The results of mitochondrial dysfunction related proteins with potential therapeutic drug molecular docking. |
| topic | Biochemistry Cell Biology Genetics Molecular Biology Biological Sciences not elsewhere classified various analytical methods transmission electron microscopy process potentially leading potential therapeutic drugs parkinson &# 8217 neurodegenerative condition characterized modulating copper metabolism mirna network highlighted induced mouse model 31 distinct modules expression network analysis differential expression analysis potential hub genes identify module genes uncovered mitochondrial alterations potential pd treatments differentially expressed cuproptosis differential gene expression early pd diagnosis disease </ p related genes associated related genes protein analysis analysis led related pathways mitochondrial function mitochondrial dysfunction pd prevention pd ), thereby enhancing sy5y cells study concluded remaining five motor deficits kyoto encyclopedia intersecting degs internal training including nadh geo database gene ontology external validation enrichment analyses dopamine neurons designating one degs ). additional scrutiny 9 ), |