Peroxisomal Compartmentalization of the Methylerythritol-4-phosphate Pathway Alleviates Cellular Stress and Enhances Geraniol Production in Saccharomyces cerevisiae

Peroxisomal Compartmentalization of the Methylerythritol-4-phosphate Pathway Alleviates Cellular Stress and Enhances Geraniol Production in Saccharomyces cerevisiae

Terpenoids are a diverse class of compounds with significant application potential. While prokaryotic bacteria synthesize terpenoids via the methylerythritol-4-phosphate (MEP) pathway, fungi utilize the mevalonate (MVA) pathway. The MVA pathway has been widely employed for efficient terpenoid produc...

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Bibliographic Details
Main Author: Jerome R. Lon (21775343) (author)
Other Authors: Xuemei Zhao (10933) (author), Gulkiz Mamatrixat (21775346) (author), Zhoukang Zhuang (8862218) (author), Zhehao Jin (14343148) (author), Tao Yu (176965) (author), Jufang Wang (91185) (author), Hongting Tang (3799657) (author)
Published: 2025
Subjects:
Biochemistry
Microbiology
Genetics
Molecular Biology
Pharmacology
Biotechnology
Immunology
Cancer
Space Science
Chemical Sciences not elsewhere classified
Information Systems not elsewhere classified
overexpression analysis revealed
offering valuable insights
additional metabolic engineering
enhance monoterpenoid production
efficient terpenoid production
saccharomyces cerevisiae terpenoids
enhancing terpenoid biosynthesis
improved geraniol production
enhances geraniol production
employed peroxisomal compartmentalization
compartmentalized mep pathway
significant application potential
cytosolic mep pathway
saccharomyces cerevisiae
peroxisomal compartmentalization
widely employed
mep pathway
cytosolic metabolism
cytosolic expression
geraniol synthase
viable approach
major contributors
initially achieved
growth inhibition
fungi utilize
findings demonstrate
factor limiting
escherichia coli
effective incorporation
diverse class
could also
64 mg
5 %.
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