Peroxisomal Compartmentalization of the Methylerythritol-4-phosphate Pathway Alleviates Cellular Stress and Enhances Geraniol Production in Saccharomyces cerevisiae

Terpenoids are a diverse class of compounds with significant application potential. While prokaryotic bacteria synthesize terpenoids via the methylerythritol-4-phosphate (MEP) pathway, fungi utilize the mevalonate (MVA) pathway. The MVA pathway has been widely employed for efficient terpenoid produc...

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Bibliographic Details
Main Author:	Jerome R. Lon (21775343) (author)
Other Authors:	Xuemei Zhao (10933) (author), Gulkiz Mamatrixat (21775346) (author), Zhoukang Zhuang (8862218) (author), Zhehao Jin (14343148) (author), Tao Yu (176965) (author), Jufang Wang (91185) (author), Hongting Tang (3799657) (author)
Published:	2025
Subjects:	Biochemistry Microbiology Genetics Molecular Biology Pharmacology Biotechnology Immunology Cancer Space Science Chemical Sciences not elsewhere classified Information Systems not elsewhere classified overexpression analysis revealed offering valuable insights additional metabolic engineering enhance monoterpenoid production efficient terpenoid production saccharomyces cerevisiae terpenoids enhancing terpenoid biosynthesis improved geraniol production enhances geraniol production employed peroxisomal compartmentalization compartmentalized mep pathway significant application potential cytosolic mep pathway saccharomyces cerevisiae peroxisomal compartmentalization widely employed mep pathway cytosolic metabolism cytosolic expression geraniol synthase viable approach major contributors initially achieved growth inhibition fungi utilize findings demonstrate factor limiting escherichia coli effective incorporation diverse class could also 64 mg 5 %.
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Peroxisomal Compartmentalization of the Methylerythritol-4-phosphate Pathway Alleviates Cellular Stress and Enhances Geraniol Production in Saccharomyces cerevisiae

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