Tau pathology in the LEC-DG pathway.

Tau pathology in the LEC-DG pathway.

<p><b>A)</b> Anterior-posterior expression of human tau in the LEC and lateral perforant pathway projection to the outer molecular layer of the DG. <b>B)</b> Adult-born tdTomato<sup>+</sup> DG granule cells in a mouse injected with rAAV-hTau-GFP. <b>C)...

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Bibliographic Details
Main Author:	Alyssa M. Ash (22821992) (author)
Other Authors:	Sue Rim Baek (22821995) (author), Peyton Holder (22821998) (author), Sara Singh (10774377) (author), Nicholas P. Vyleta (10994422) (author), Matthew Willman (11940338) (author), Kevin R. Nash (9246094) (author), Jason S. Snyder (10994425) (author)
Published:	2025
Subjects:	Biochemistry Cell Biology Neuroscience Physiology Developmental Biology Mental Health reduced dendritic complexity insoluble amyloid plaques expressing recombinant adeno early postnatal development dentate gyrus subregion disease cell death human dentate gyrus female asclcreer mice since immature neurons lateral entorhinal cortex hippocampus </ p female mice dentate pathway human tau entorhinal cortex disease varies born neurons uniquely responsive thin spines term potentiation synaptic input spine addition specific effect related memory pathological tau output curves novel model neurofibrillary tangles mushroom spines mouse model male mice known roles hippocampal formation earliest stages broadly characterized associated virus
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