S2 Fig -

S2 Fig -

<p><b>A,</b> Blood CFU from infant and adult mice intraperitoneally (IP) infected with 10<sup>2</sup> CFU of <i>Spn</i> T6A at 1 dpi (n = 8–13). Statistical significance determined using Mann-Whitney test. ns, not significant. Data represent individual mice...

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Bibliographic Details
Main Author:	Kristen L. Lokken-Toyli (9455263) (author)
Other Authors:	Surya D. Aggarwal (5849162) (author), Gavyn Chern Wei Bee (16765028) (author), Wouter A. A. de Steenhuijsen Piters (18522849) (author), Cindy Wu (3238686) (author), Kenny Zhi Ming Chen (18522852) (author), Cynthia Loomis (10526353) (author), Debby Bogaert (23222) (author), Jeffrey N. Weiser (10526356) (author)
Published:	2024
Subjects:	Biochemistry Medicine Microbiology Cell Biology Genetics Molecular Biology Physiology Immunology Developmental Biology Cancer Infectious Diseases Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified using molecular barcoding tight junction pathway like receptor 2 forming toxin pneumolysin first two weeks delayed mucociliary clearance streptococcus pneumoniae </ significantly decreased compared drive bacterial spread upregulate genes involved postnatal development predisposes div >< p urt epithelium revealed early life beyond postnatal development spn </ respiratory epithelium early life also decreased bacterial clones urt monocyte urt barrier transcriptional profiling tighter attachment survival rate results demonstrate pneumococcal bacteremia newborn period neutrophil infiltration nasopharynx disseminated invasive respiratory inflammation mediated infant mice increased rate highly susceptible gastrointestinal infections derived ros dependent mechanism colonization levels
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