GPX4 inhibition abolished modulatory effects of PMS on ferroptosis and xCT/GPX4 pathway.

(a-c) The effects of PMS on the levels of GSH (a) and GSSG (b), and on GSH/GSSG (c) ratio were abolished after RSL-3 treatment. (d-f) RT-qPCR results show that RSL-3 abolished the effects of PMS on the mRNA expression of Slc7a11 (d), Slc3a2 (e), and <...

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Главный автор:	Hongmin Zhao (20710544) (author)
Другие авторы:	Renlin Li (21439962) (author), Xuan Guo (1791202) (author), Jingrui Kang (21578315) (author), Huajun Li (8309904) (author), Xiaoyun Wang (148866) (author), Yuansong Wang (14103603) (author), Huantian Cui (5798996) (author), Shuquan Lv (11897978) (author), Weibo Wen (8115296) (author), Zhongyong Zhang (11887698) (author)
Опубликовано:	2025
Предметы:	Biophysics Biochemistry Cell Biology Genetics Molecular Biology Pharmacology Biotechnology Immunology Cancer Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified mechanisms remain unclear pancreatic &# 946 upregulated factors linked t2dm ), may improving t2dm outcomes pancreatic islet β alleviating cellular damage ferroptosis inhibitor ferrostatin div >< p gpx4 inhibitor rsl ferroptosis inhibitor fer pms alleviated hg t2dm via activation gpx4 pathway modulation pancreatic β factors associated t2dm mice gpx4 pathway gpx4 axis cells via tissue damage induced damage induce damage diminish damage cell damage suppressing ferroptosis suppressed ferroptosis reduced ferroptosis inhibiting ferroptosis inhibit ferroptosis vivo </ vitro </ shows promise positive control pms exhibited palmitic acid lipid peroxidation key pathology glutamate transporter findings revealed beneficial impacts 3 attenuated
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GPX4 inhibition abolished modulatory effects of PMS on ferroptosis and xCT/GPX4 pathway.

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