Label propagation is robust to biomarker panel composition, tracking efficiency, and tissue type.

<p><b>(A)</b> Overview of single-slide validation experiment. Ground-truth cell type clusters were generated on all cells and all biomarkers for a tissue section dataset. Across a range of proportions, the cells were split into ‘tracked’ (green) and ‘untracked’ (yellow) matrices. W...

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Bibliographic Details
Main Author:	Robert T. Heussner (21989911) (author)
Other Authors:	Cameron F. Watson (21989914) (author), Christopher Z. Eddy (21989917) (author), Kunlun Wang (2794564) (author), Eric M. Cramer (10499236) (author), Allison L. Creason (8887589) (author), Gordon B. Mills (6841554) (author), Young Hwan Chang (10276110) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Medicine Cell Biology Molecular Biology Biotechnology Immunology Developmental Biology Cancer Hematology Infectious Diseases Virology Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified unique biomarker panels inherent biological heterogeneity first use monte comprehensively profile samples although image registration mti &# 8217 demonstrate coexist necessity improved spatial single cell level poses mti panel size single mti panel panel size cell level spatial information mti platforms single slide coordinated single cell resolution cell profiling cell lineages thick sections technological limitations serial sections novel algorithm introduce coexist intact nuclei incompatible multi full nuclei effectively completing consecutive sections challenge due carlo simulations assay protocols also overcomes
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Label propagation is robust to biomarker panel composition, tracking efficiency, and tissue type.

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