The free energy landscapes of unbinding the C-terminus from the GPR1 pocket.

<p><b>(A)</b> 2D projection of unbinding free energy of C9-GPR1 complex (first column) and full-length chemerin-GPR1 complex (second-fourth columns). Arrows mark the high energy states of unbinding along the reaction coordinates of tica_Z and tica_BETA, respectively. <b>(B)&l...

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Bibliographic Details
Main Author:	Aijun Liu (5579711) (author)
Other Authors:	Yezhou Liu (6718037) (author), Geng Chen (194556) (author), Wenping Lyu (3773128) (author), Fang Ye (112854) (author), Junlin Wang (4029803) (author), Qiwen Liao (3905665) (author), Lizhe Zhu (383604) (author), Yang Du (506908) (author), Richard D. Ye (2353900) (author)
Published:	2024
Subjects:	Biophysics Biochemistry Cell Biology Molecular Biology Evolutionary Biology Inorganic Chemistry Infectious Diseases Chemical Sciences not elsewhere classified Physical Sciences not elsewhere classified molecular dynamics simulations site &# 8221 lid &# 8221 coupled receptor 1 xlink "> chemerin like receptor 1 structural model explains length chemerin uses 3 g protein coupled gpr1 bound tm binding pocket c chemokine receptor length chemerin g protein binding pocket coupled receptors &# 8220 like 2 chemerin binds yfpgqfafs ). terminal nonapeptide terminal core resolution cryo present high including chemokine gpr1 signaling gpr1 ), functional assays energetically expensive em structures combining results chemotactic activity ccrl2 ). activating peptide
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The free energy landscapes of unbinding the C-terminus from the GPR1 pocket.

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