Clinical and demographic characteristics of nursing home residents receiving concomitant antidepressant-opioid use overall, and by CYP2D6-inhibiting vs. CYP2D6-neutral antidepressants.

Clinical and demographic characteristics of nursing home residents receiving concomitant antidepressant-opioid use overall, and by CYP2D6-inhibiting vs. CYP2D6-neutral antidepressants.

<p>Clinical and demographic characteristics of nursing home residents receiving concomitant antidepressant-opioid use overall, and by CYP2D6-inhibiting vs. CYP2D6-neutral antidepressants.</p>

محفوظ في:
التفاصيل البيبلوغرافية
المؤلف الرئيسي: Yu-Jung Jenny Wei (7821602) (author)
مؤلفون آخرون: Almut G. Winterstein (7821608) (author), Siegfried Schmidt (9635665) (author), Roger B. Fillingim (7299116) (author), Michael J. Daniels (8728683) (author), Steven T. DeKosky (11035134) (author), Stephan Schmidt (394425) (author)
منشور في: 2025
الموضوعات:
Medicine
Pharmacology
Biotechnology
Cancer
Science Policy
Mental Health
Infectious Diseases
previous literature showed
participants included long
nursing home discharge
minimum data set
least 30 days
incidence rate ratio
higher incidence rate
antidepressant interactions may
already receiving antidepressants
metabolizing opioids concomitantly
e ., opioid
potential worsening pain
6 %, 1
e ., antidepressant
ed visits due
opioid use disorder
triggered interaction ),
rd ): 1
pain among patients
irr ]: 1
related ed visits
neutral antidepressants concomitantly
inhibiting versus cyp2d6
triggered interaction
antidepressants concomitantly
worsening pain
versus cyp2d6
related hospitalizations
pharmacokinetic opioid
opioid overdose
metabolized opioids
higher risk
6 %])
per 1
january 1
day 1
1 year
existing antidepressants
years ),
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used cyp2d6
two drugs
treatment weighting
term residents
study aims
physical function
medicare claims
key exposure
initiating cyp2d6
increased risk
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