Untargeted Diversity-Oriented Synthesis for the Discovery of New Antitumor Agents: An Integrated Approach of Inverse Virtual Screening, Bioinformatics, and Omics for Target Deconvolution

Molecular diversity is one of the most pursued objectives in drug discovery, and diversity-oriented synthesis (DOS) perfectly responds to the achievement of this goal. In this paper, we describe a DOS approach applied to the antitumor field with the aim of identifying new anticancer structures and t...

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Autore principale:	Tania Ciaglia (1810390) (author)
Altri autori:	Valeria Napolitano (8231475) (author), Maria Rosaria Miranda (19195359) (author), Danila La Gioia (17670570) (author), Simona Musella (1810387) (author), Aniello Schiano Moriello (250111) (author), Fabrizio Merciai (7213442) (author), Veronica Di Sarno (7213436) (author), Simona De Vita (7646621) (author), Ester Colarusso (8554359) (author), Gerardina Smaldone (9251686) (author), Francesca Di Matteo (14041561) (author), Eduardo Maria Sommella (16390716) (author), Poulami Kumar (17987310) (author), Marco Allarà (1343205) (author), Alessia Ligresti (250102) (author), Isabel M. Gomez-Monterrey (4590862) (author), Giuseppe Bifulco (186812) (author), Gianluigi Lauro (1355385) (author), Pietro Campiglia (405663) (author), Carmine Ostacolo (1717276) (author), Vincenzo Vestuto (7213439) (author), Alessia Bertamino (447718) (author)
Pubblicazione:	2025
Soggetti:	Biophysics Biochemistry Medicine Microbiology Pharmacology Biotechnology Science Policy Plant Biology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified work allowed us several proteins emerged inverse virtual screening endoplasmic reticulum stress new antitumor agents six targets involved interesting antitumor mechanism ivs ), bioinformatics 31 </ b untargeted dos campaigns dos approach applied antitumor field interesting ones integrated approach biological targets associated targets untargeted diversity pursued objectives promising compounds phenotypic evaluation perfectly responds oriented synthesis initial stage fruitful tool cellulo experiments calcium regulation ambitious project
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Untargeted Diversity-Oriented Synthesis for the Discovery of New Antitumor Agents: An Integrated Approach of Inverse Virtual Screening, Bioinformatics, and Omics for Target Deconvolution

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