Case accrual process.
<div><p>Purpose</p><p>To evaluate the prognostic significance of venographic findings and procedural factors for long-term venous patency after thrombectomy in patients with May-Thurner syndrome (MTS)-associated deep vein thrombosis (DVT).</p><p>Materials and Meth...
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2025
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| _version_ | 1849927627613143040 |
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| author | Chang Hoon Oh (16786347) |
| author2 | In Chul Nam (11307676) Doo Ri Kim (14059684) Jung Ho Won (7871465) Hyoung Nam Lee (14106504) Sung-Joon Park (548075) Youngjong Cho (10052659) |
| author2_role | author author author author author author |
| author_facet | Chang Hoon Oh (16786347) In Chul Nam (11307676) Doo Ri Kim (14059684) Jung Ho Won (7871465) Hyoung Nam Lee (14106504) Sung-Joon Park (548075) Youngjong Cho (10052659) |
| author_role | author |
| dc.creator.none.fl_str_mv | Chang Hoon Oh (16786347) In Chul Nam (11307676) Doo Ri Kim (14059684) Jung Ho Won (7871465) Hyoung Nam Lee (14106504) Sung-Joon Park (548075) Youngjong Cho (10052659) |
| dc.date.none.fl_str_mv | 2025-11-25T18:33:01Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pone.0336037.g001 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Case_accrual_process_/30714265 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biochemistry Medicine Cell Biology Molecular Biology Biotechnology Developmental Biology Cancer Infectious Diseases multivariate cox model kaplan &# 8211 iliofemoral dvt secondary effective anatomical resolution 28 – 19 month venous patency related confounding factors meier survival analysis term venous patency independently predict patency hr ]= 5 term patency reduced patency procedural factors independently associated xlink "> whereas 17 venographic findings univariate analysis thurner syndrome stent placement stent deployment prospective studies prognostic significance prognostic impact primary outcome persistent collaterals likely due january 2011 independent predictor hazard ratio confidence interval better outcomes april 2023 05 ). 021 ). |
| dc.title.none.fl_str_mv | Case accrual process. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <div><p>Purpose</p><p>To evaluate the prognostic significance of venographic findings and procedural factors for long-term venous patency after thrombectomy in patients with May-Thurner syndrome (MTS)-associated deep vein thrombosis (DVT).</p><p>Materials and Methods</p><p>This retrospective cohort study included 75 patients with iliofemoral DVT secondary to MTS, who underwent thrombectomy between January 2011 and April 2023. Key venographic findings—venous stenosis (≥50%), venous spur, and persistent collaterals—along with stent placement and diameter were analyzed. The primary outcome was 24-month venous patency, assessed using univariate tests, Kaplan–Meier survival analysis, and multivariate Cox proportional hazards modeling.</p><p>Results</p><p>At 24 months, 58 patients (77.3%) maintained venous patency, whereas 17 (22.7%) experienced reocclusion. Univariate and Kaplan–Meier analyses showed that stenosis ≥50%, venous spur, persistent collaterals, and absence of stent placement were significantly associated with reduced patency (all <i>p</i> < 0.05). However, in the multivariate Cox model, only venous stenosis ≥50% remained a statistically significant independent predictor of reocclusion (hazard ratio [HR]=5.04; 95% Confidence Interval: 1.28–19.82; <i>p</i> = 0.021). Stent placement (HR = 1.78; <i>p</i> = 0.337) and diameter (<i>p</i> = 0.349) were not independently associated with patency.</p><p>Conclusion</p><p>Residual venous stenosis ≥50% following thrombectomy is an independent predictor of reduced long-term patency in patients with MTS. While stent placement was associated with better outcomes in the univariate analysis, it did not independently predict patency after adjustment, likely due to treatment-related confounding factors. Effective anatomical resolution of stenosis may be more critical than stent deployment. Prospective studies are warranted to clarify the prognostic impact of venographic findings and interventional strategies.</p></div> |
| eu_rights_str_mv | openAccess |
| id | Manara_fe6d073882ba75341fe88c08ee207f2c |
| identifier_str_mv | 10.1371/journal.pone.0336037.g001 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30714265 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Case accrual process.Chang Hoon Oh (16786347)In Chul Nam (11307676)Doo Ri Kim (14059684)Jung Ho Won (7871465)Hyoung Nam Lee (14106504)Sung-Joon Park (548075)Youngjong Cho (10052659)BiochemistryMedicineCell BiologyMolecular BiologyBiotechnologyDevelopmental BiologyCancerInfectious Diseasesmultivariate cox modelkaplan &# 8211iliofemoral dvt secondaryeffective anatomical resolution28 – 19month venous patencyrelated confounding factorsmeier survival analysisterm venous patencyindependently predict patencyhr ]= 5term patencyreduced patencyprocedural factorsindependently associatedxlink ">whereas 17venographic findingsunivariate analysisthurner syndromestent placementstent deploymentprospective studiesprognostic significanceprognostic impactprimary outcomepersistent collateralslikely duejanuary 2011independent predictorhazard ratioconfidence intervalbetter outcomesapril 202305 ).021 ).<div><p>Purpose</p><p>To evaluate the prognostic significance of venographic findings and procedural factors for long-term venous patency after thrombectomy in patients with May-Thurner syndrome (MTS)-associated deep vein thrombosis (DVT).</p><p>Materials and Methods</p><p>This retrospective cohort study included 75 patients with iliofemoral DVT secondary to MTS, who underwent thrombectomy between January 2011 and April 2023. Key venographic findings—venous stenosis (≥50%), venous spur, and persistent collaterals—along with stent placement and diameter were analyzed. The primary outcome was 24-month venous patency, assessed using univariate tests, Kaplan–Meier survival analysis, and multivariate Cox proportional hazards modeling.</p><p>Results</p><p>At 24 months, 58 patients (77.3%) maintained venous patency, whereas 17 (22.7%) experienced reocclusion. Univariate and Kaplan–Meier analyses showed that stenosis ≥50%, venous spur, persistent collaterals, and absence of stent placement were significantly associated with reduced patency (all <i>p</i> < 0.05). However, in the multivariate Cox model, only venous stenosis ≥50% remained a statistically significant independent predictor of reocclusion (hazard ratio [HR]=5.04; 95% Confidence Interval: 1.28–19.82; <i>p</i> = 0.021). Stent placement (HR = 1.78; <i>p</i> = 0.337) and diameter (<i>p</i> = 0.349) were not independently associated with patency.</p><p>Conclusion</p><p>Residual venous stenosis ≥50% following thrombectomy is an independent predictor of reduced long-term patency in patients with MTS. While stent placement was associated with better outcomes in the univariate analysis, it did not independently predict patency after adjustment, likely due to treatment-related confounding factors. Effective anatomical resolution of stenosis may be more critical than stent deployment. Prospective studies are warranted to clarify the prognostic impact of venographic findings and interventional strategies.</p></div>2025-11-25T18:33:01ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pone.0336037.g001https://figshare.com/articles/figure/Case_accrual_process_/30714265CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/307142652025-11-25T18:33:01Z |
| spellingShingle | Case accrual process. Chang Hoon Oh (16786347) Biochemistry Medicine Cell Biology Molecular Biology Biotechnology Developmental Biology Cancer Infectious Diseases multivariate cox model kaplan &# 8211 iliofemoral dvt secondary effective anatomical resolution 28 – 19 month venous patency related confounding factors meier survival analysis term venous patency independently predict patency hr ]= 5 term patency reduced patency procedural factors independently associated xlink "> whereas 17 venographic findings univariate analysis thurner syndrome stent placement stent deployment prospective studies prognostic significance prognostic impact primary outcome persistent collaterals likely due january 2011 independent predictor hazard ratio confidence interval better outcomes april 2023 05 ). 021 ). |
| status_str | publishedVersion |
| title | Case accrual process. |
| title_full | Case accrual process. |
| title_fullStr | Case accrual process. |
| title_full_unstemmed | Case accrual process. |
| title_short | Case accrual process. |
| title_sort | Case accrual process. |
| topic | Biochemistry Medicine Cell Biology Molecular Biology Biotechnology Developmental Biology Cancer Infectious Diseases multivariate cox model kaplan &# 8211 iliofemoral dvt secondary effective anatomical resolution 28 – 19 month venous patency related confounding factors meier survival analysis term venous patency independently predict patency hr ]= 5 term patency reduced patency procedural factors independently associated xlink "> whereas 17 venographic findings univariate analysis thurner syndrome stent placement stent deployment prospective studies prognostic significance prognostic impact primary outcome persistent collaterals likely due january 2011 independent predictor hazard ratio confidence interval better outcomes april 2023 05 ). 021 ). |