Copper-Catalyzed Regioselective Hydroamination and Dual Annulation of 2‑Alkynyl Indole-3-carbonitriles: An Assembly of Functionalized Amino-Benzo[<i>h</i>]indolo[3,2‑<i>c</i>][1,6]naphthyridines

Copper-Catalyzed Regioselective Hydroamination and Dual Annulation of 2‑Alkynyl Indole-3-carbonitriles: An Assembly of Functionalized Amino-Benzo[<i>h</i>]indolo[3,2‑<i>c</i>][1,6]naphthyridines

Presented herein are the copper-catalyzed regioselective hydroamination and successive dual annulation of 2-alkynyl indole-3-carbonitriles. The reaction shows a general approach for the versatile synthesis of amino-benzo[<i>h</i>]indolo[3,2-<i>c</i>][1,6]naphthyridines under...

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Detalhes bibliográficos
Autor principal: Debanik Panda (20938707) (author)
Outros Autores: Ankit Kumar (1723507) (author), Nidhi (9293151) (author), Akhilesh K. Verma (1489840) (author)
Publicado em: 2025
Assuntos:
Biochemistry
Physiology
Mental Health
Computational Biology
cyano (- cn
broad substrate scope
absolute atom economy
successive dual annulation
naphthyridines presented herein
catalyzed regioselective hydroamination
alkyne functional group
dual annulation
hydroamination process
highly regioselective
versatile synthesis
transformation shows
stage modification
reaction shows
proposed mechanism
postsynthetic transformation
mild conditions
h </
general approach
c </
benzo [<
alkynyl indole
>][ 1
>] indolo
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