Recombinant mapping narrows region of interest to identify a loss-of-function allele of mttp.

A) markers Aa and Ba were outputted by WheresWalker and used to genotype arches mutants in order to identify recombinants. M and F denote male and female parents, respectively. PCR product sizes for wild-type and mutant (highl...

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Main Author:	McKenna Feltes (11242085) (author)
Other Authors:	Aleksey V. Zimin (8363328) (author), Sofia Angel (21714119) (author), Nainika Pansari (21714122) (author), Monica R. Hensley (3133671) (author), Jennifer L. Anderson (15991713) (author), Meng-Chieh Shen (4608190) (author), Mackenzie Klemek (21714125) (author), Yi Shen (152956) (author), Vighnesh S. Ginde (21714128) (author), Hannah Kozan (21714131) (author), Nhan V. Le (21714134) (author), Vivian P. Truong (21714137) (author), Meredith H. Wilson (6816489) (author), Steven L. Salzberg (8363331) (author), Steven A. Farber (9217109) (author)
Published:	2025
Subjects:	Medicine Microbiology Genetics Neuroscience Evolutionary Biology Infectious Diseases Virology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified supports positional cloning method using mutants forward genetic screening allelic frequency calculations whereswalker correctly mapped sequencing approach based previously unappreciated apob previously published mutation div >< p sequencing algorithm powerful approach describe whereswalker slc3a2a </ potential candidates mttp </ modifying locus mia2 </ lipoprotein metabolism key step gene causing drastically reduces assign functions 1 </
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Recombinant mapping narrows region of interest to identify a loss-of-function allele of <i>mttp.</i>

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