Discovery of Cysteine Carboxyalkylations by Real-Time Isotopic Signature Targeted Profiling

Data-dependent acquisition (DDA) is widely applied in shotgun proteomics. However, restricted by the scanning speed of mass spectrometry (MS) instruments, it remains challenging for DDA to directly detect peptides with low abundance. Herein, we developed a real-time targeted MS data acquisition meth...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Guogeng Jia (5497871) (author)
مؤلفون آخرون:	Yicheng Liu (2179626) (author), Tianyu Feng (2544430) (author), Zixuan Zhang (6957035) (author), Huan Tang (334333) (author), Fan Yang (1413) (author), Ziyao Tang (8202003) (author), Weidi Xiao (1403551) (author), Ying Chen (9697) (author), Jinjun Gao (528119) (author), Chu Wang (62506) (author)
منشور في:	2025
الموضوعات:	Biophysics Biochemistry Medicine Pharmacology Sociology Immunology Space Science Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified unique isotopic signatures identifying target peptides identifies target peptides fatty acid metabolism directly detect peptides “ isostar ”, ms scans immediately low abundance compared low abundance widely applied versatile tool targeted ms shotgun proteomics scanning speed remains challenging profiling protein ms scanning mass spectrometry dependent acquisition centric modifications
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Discovery of Cysteine Carboxyalkylations by Real-Time Isotopic Signature Targeted Profiling

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