Data Sheet 1_GM-CSF and IL-21-armed oncolytic vaccinia virus significantly enhances anti-tumor activity and synergizes with anti-PD1 immunotherapy in pancreatic cancer.docx

Data Sheet 1_GM-CSF and IL-21-armed oncolytic vaccinia virus significantly enhances anti-tumor activity and synergizes with anti-PD1 immunotherapy in pancreatic cancer.docx

<p>Pancreatic cancer is one of the most aggressive cancers and poses significant challenges to current therapies because of its complex immunosuppressive tumor microenvironment (TME). Oncolytic viruses armed with immunoregulatory molecules are promising strategies to overcome limited efficacy...

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Bibliographic Details
Main Author: Yujing Xuan (8062175) (author)
Other Authors: Wenyi Yan (9504903) (author), Ruimin Wang (317092) (author), Xibin Wang (3135924) (author), Yu Guo (102701) (author), Huilin Dun (20498258) (author), Ziyan Huan (20498261) (author), Lihua Xu (534555) (author), Ruxia Han (11053320) (author), Xianlei Sun (1697218) (author), Lingling Si (12704724) (author), Nicholas R. Lemoine (9125847) (author), Yaohe Wang (85674) (author), Pengju Wang (5019086) (author)
Published: 2025
Subjects:
Genetic Immunology
oncolytic vaccinia virus
GM-CSF
IL-21
pancreatic cancer
anti-PD1
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