A Simulation Study of the Role of Mechanical Stretch in Arrhythmogenesis during Cardiac Alternans
The deformation of the heart tissue due to the contraction can modulate the excitation, a phenomenon referred to as mechanoelectrical feedback (MEF), via stretch-activated channels. The effects of MEF on the electrophysiology at high pacing rates are shown to be proarrhythmic in general. However, mo...
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2021
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| Online Access: | http://hdl.handle.net/11073/25363 |
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| _version_ | 1864513440246136832 |
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| author | Hazim, Azzam |
| author2 | Belhamadia, Youssef Dubljevic, Stevan |
| author2_role | author author |
| author_facet | Hazim, Azzam Belhamadia, Youssef Dubljevic, Stevan |
| author_role | author |
| dc.creator.none.fl_str_mv | Hazim, Azzam Belhamadia, Youssef Dubljevic, Stevan |
| dc.date.none.fl_str_mv | 2021-01 2023-09-22T10:30:35Z 2023-09-22T10:30:35Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Hazim, A., Belhamadia, Y., & Dubljevic, S. (2021). A Simulation Study of the Role of Mechanical Stretch in Arrhythmogenesis during Cardiac Alternans. In Biophysical Journal (Vol. 120, Issue 1, pp. 109–121). Elsevier BV. https://doi.org/10.1016/j.bpj.2020.11.018 1542-0086 http://hdl.handle.net/11073/25363 10.1016/j.bpj.2020.11.018 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | Biophysical Society |
| dc.relation.none.fl_str_mv | https://doi.org/10.1016/j.bpj.2020.11.018 |
| dc.title.none.fl_str_mv | A Simulation Study of the Role of Mechanical Stretch in Arrhythmogenesis during Cardiac Alternans |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | The deformation of the heart tissue due to the contraction can modulate the excitation, a phenomenon referred to as mechanoelectrical feedback (MEF), via stretch-activated channels. The effects of MEF on the electrophysiology at high pacing rates are shown to be proarrhythmic in general. However, more studies need to be done to elucidate the underlying mechanism. In this work, we investigate the effects of MEF on cardiac alternans, which is an alternation in the width of the action potential that typically occurs when the heart is paced at high rates, using a biophysically detailed electromechanical model of cardiac tissue. We observe that the transition from spatially concordant alternans to spatially discordant alternans, which is more arrhythmogenic than concordant alternans, may occur in the presence of MEF and when its strength is sufficiently large. We show that this transition is due to the increase of the dispersion of conduction velocity. In addition, our results also show that the MEF effects, depending on the stretch-activated channels’ conductances and reversal potentials, can result in blocking action potential propagation. |
| format | article |
| id | aus_43f2285a74b7bdccdfb7f16638f3a96b |
| identifier_str_mv | Hazim, A., Belhamadia, Y., & Dubljevic, S. (2021). A Simulation Study of the Role of Mechanical Stretch in Arrhythmogenesis during Cardiac Alternans. In Biophysical Journal (Vol. 120, Issue 1, pp. 109–121). Elsevier BV. https://doi.org/10.1016/j.bpj.2020.11.018 1542-0086 10.1016/j.bpj.2020.11.018 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/25363 |
| publishDate | 2021 |
| publisher.none.fl_str_mv | Biophysical Society |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | A Simulation Study of the Role of Mechanical Stretch in Arrhythmogenesis during Cardiac AlternansHazim, AzzamBelhamadia, YoussefDubljevic, StevanThe deformation of the heart tissue due to the contraction can modulate the excitation, a phenomenon referred to as mechanoelectrical feedback (MEF), via stretch-activated channels. The effects of MEF on the electrophysiology at high pacing rates are shown to be proarrhythmic in general. However, more studies need to be done to elucidate the underlying mechanism. In this work, we investigate the effects of MEF on cardiac alternans, which is an alternation in the width of the action potential that typically occurs when the heart is paced at high rates, using a biophysically detailed electromechanical model of cardiac tissue. We observe that the transition from spatially concordant alternans to spatially discordant alternans, which is more arrhythmogenic than concordant alternans, may occur in the presence of MEF and when its strength is sufficiently large. We show that this transition is due to the increase of the dispersion of conduction velocity. In addition, our results also show that the MEF effects, depending on the stretch-activated channels’ conductances and reversal potentials, can result in blocking action potential propagation.Natural Sciences and Engineering Research Council of CanadaAmerican University of SharjahBiophysical Society2023-09-22T10:30:35Z2023-09-22T10:30:35Z2021-01Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfHazim, A., Belhamadia, Y., & Dubljevic, S. (2021). A Simulation Study of the Role of Mechanical Stretch in Arrhythmogenesis during Cardiac Alternans. In Biophysical Journal (Vol. 120, Issue 1, pp. 109–121). Elsevier BV. https://doi.org/10.1016/j.bpj.2020.11.0181542-0086http://hdl.handle.net/11073/2536310.1016/j.bpj.2020.11.018en_UShttps://doi.org/10.1016/j.bpj.2020.11.018oai:repository.aus.edu:11073/253632024-08-22T12:01:33Z |
| spellingShingle | A Simulation Study of the Role of Mechanical Stretch in Arrhythmogenesis during Cardiac Alternans Hazim, Azzam |
| status_str | publishedVersion |
| title | A Simulation Study of the Role of Mechanical Stretch in Arrhythmogenesis during Cardiac Alternans |
| title_full | A Simulation Study of the Role of Mechanical Stretch in Arrhythmogenesis during Cardiac Alternans |
| title_fullStr | A Simulation Study of the Role of Mechanical Stretch in Arrhythmogenesis during Cardiac Alternans |
| title_full_unstemmed | A Simulation Study of the Role of Mechanical Stretch in Arrhythmogenesis during Cardiac Alternans |
| title_short | A Simulation Study of the Role of Mechanical Stretch in Arrhythmogenesis during Cardiac Alternans |
| title_sort | A Simulation Study of the Role of Mechanical Stretch in Arrhythmogenesis during Cardiac Alternans |
| url | http://hdl.handle.net/11073/25363 |