Anti-Bacterial and Anti-Fungal Activity of Xanthones Obtained via Semi-Synthetic Modification of α-Mangostin from Garcinia mangostana
The microbial contamination in food packaging has been a major concern that has paved the way to search for novel, natural anti-microbial agents, such as modified α-mangostin. In the present study, twelve synthetic analogs were obtained through semi-synthetic modification of α-mangostin by Ritter re...
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2017
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| Online Access: | http://hdl.handle.net/11073/25048 |
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| _version_ | 1864513440298565632 |
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| author | Narasimhan, Srinivasan |
| author2 | Maheshwaran, Shanmugam Abu-Yousef, Imad Majdalawieh, Amin Rethavathi, Janarthanam Das, Prince Edwin Poltronieri, Palmiro |
| author2_role | author author author author author author |
| author_facet | Narasimhan, Srinivasan Maheshwaran, Shanmugam Abu-Yousef, Imad Majdalawieh, Amin Rethavathi, Janarthanam Das, Prince Edwin Poltronieri, Palmiro |
| author_role | author |
| dc.creator.none.fl_str_mv | Narasimhan, Srinivasan Maheshwaran, Shanmugam Abu-Yousef, Imad Majdalawieh, Amin Rethavathi, Janarthanam Das, Prince Edwin Poltronieri, Palmiro |
| dc.date.none.fl_str_mv | 2017 2022-10-25T07:15:48Z 2022-10-25T07:15:48Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Narasimhan, S.; Maheshwaran, S.; Abu-Yousef, I.A.; Majdalawieh, A.F.; Rethavathi, J.; Das, P.E.; Poltronieri, P. Anti-Bacterial and Anti-Fungal Activity of Xanthones Obtained via Semi-Synthetic Modification of α-Mangostin from Garcinia mangostana. Molecules 2017, 22, 275. https://doi.org/10.3390/molecules22020275 [This article belongs to the Special Issue Frontiers in Antimicrobial Drug Discovery and Design] 1420-3049 http://hdl.handle.net/11073/25048 10.3390/molecules22020275 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.relation.none.fl_str_mv | https://doi.org/10.3390/molecules22020275 |
| dc.subject.none.fl_str_mv | Semi-synthetic modification Biomedical device Textiles Packaging Anti-fungal Anti-bacterial α-Mangostin |
| dc.title.none.fl_str_mv | Anti-Bacterial and Anti-Fungal Activity of Xanthones Obtained via Semi-Synthetic Modification of α-Mangostin from Garcinia mangostana |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | The microbial contamination in food packaging has been a major concern that has paved the way to search for novel, natural anti-microbial agents, such as modified α-mangostin. In the present study, twelve synthetic analogs were obtained through semi-synthetic modification of α-mangostin by Ritter reaction, reduction by palladium-carbon (Pd-C), alkylation, and acetylation. The evaluation of the anti-microbial potential of the synthetic analogs showed higher bactericidal activity than the parent molecule. The anti-microbial studies proved that I E showed high anti-bacterial activity whereas I I showed the highest anti-fungal activity. Due to their microbicidal potential, modified α-mangostin derivatives could be utilized as active anti-microbial agents in materials for the biomedical and food industry. |
| format | article |
| id | aus_dcda3382c5f78d5aa121f9ee770224ea |
| identifier_str_mv | Narasimhan, S.; Maheshwaran, S.; Abu-Yousef, I.A.; Majdalawieh, A.F.; Rethavathi, J.; Das, P.E.; Poltronieri, P. Anti-Bacterial and Anti-Fungal Activity of Xanthones Obtained via Semi-Synthetic Modification of α-Mangostin from Garcinia mangostana. Molecules 2017, 22, 275. https://doi.org/10.3390/molecules22020275 [This article belongs to the Special Issue Frontiers in Antimicrobial Drug Discovery and Design] 1420-3049 10.3390/molecules22020275 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/25048 |
| publishDate | 2017 |
| publisher.none.fl_str_mv | MDPI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Anti-Bacterial and Anti-Fungal Activity of Xanthones Obtained via Semi-Synthetic Modification of α-Mangostin from Garcinia mangostanaNarasimhan, SrinivasanMaheshwaran, ShanmugamAbu-Yousef, ImadMajdalawieh, AminRethavathi, JanarthanamDas, Prince EdwinPoltronieri, PalmiroSemi-synthetic modificationBiomedical deviceTextilesPackagingAnti-fungalAnti-bacterialα-MangostinThe microbial contamination in food packaging has been a major concern that has paved the way to search for novel, natural anti-microbial agents, such as modified α-mangostin. In the present study, twelve synthetic analogs were obtained through semi-synthetic modification of α-mangostin by Ritter reaction, reduction by palladium-carbon (Pd-C), alkylation, and acetylation. The evaluation of the anti-microbial potential of the synthetic analogs showed higher bactericidal activity than the parent molecule. The anti-microbial studies proved that I E showed high anti-bacterial activity whereas I I showed the highest anti-fungal activity. Due to their microbicidal potential, modified α-mangostin derivatives could be utilized as active anti-microbial agents in materials for the biomedical and food industry.MDPI2022-10-25T07:15:48Z2022-10-25T07:15:48Z2017Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfNarasimhan, S.; Maheshwaran, S.; Abu-Yousef, I.A.; Majdalawieh, A.F.; Rethavathi, J.; Das, P.E.; Poltronieri, P. Anti-Bacterial and Anti-Fungal Activity of Xanthones Obtained via Semi-Synthetic Modification of α-Mangostin from Garcinia mangostana. Molecules 2017, 22, 275. https://doi.org/10.3390/molecules22020275 [This article belongs to the Special Issue Frontiers in Antimicrobial Drug Discovery and Design]1420-3049http://hdl.handle.net/11073/2504810.3390/molecules22020275en_UShttps://doi.org/10.3390/molecules22020275oai:repository.aus.edu:11073/250482024-08-22T11:59:34Z |
| spellingShingle | Anti-Bacterial and Anti-Fungal Activity of Xanthones Obtained via Semi-Synthetic Modification of α-Mangostin from Garcinia mangostana Narasimhan, Srinivasan Semi-synthetic modification Biomedical device Textiles Packaging Anti-fungal Anti-bacterial α-Mangostin |
| status_str | publishedVersion |
| title | Anti-Bacterial and Anti-Fungal Activity of Xanthones Obtained via Semi-Synthetic Modification of α-Mangostin from Garcinia mangostana |
| title_full | Anti-Bacterial and Anti-Fungal Activity of Xanthones Obtained via Semi-Synthetic Modification of α-Mangostin from Garcinia mangostana |
| title_fullStr | Anti-Bacterial and Anti-Fungal Activity of Xanthones Obtained via Semi-Synthetic Modification of α-Mangostin from Garcinia mangostana |
| title_full_unstemmed | Anti-Bacterial and Anti-Fungal Activity of Xanthones Obtained via Semi-Synthetic Modification of α-Mangostin from Garcinia mangostana |
| title_short | Anti-Bacterial and Anti-Fungal Activity of Xanthones Obtained via Semi-Synthetic Modification of α-Mangostin from Garcinia mangostana |
| title_sort | Anti-Bacterial and Anti-Fungal Activity of Xanthones Obtained via Semi-Synthetic Modification of α-Mangostin from Garcinia mangostana |
| topic | Semi-synthetic modification Biomedical device Textiles Packaging Anti-fungal Anti-bacterial α-Mangostin |
| url | http://hdl.handle.net/11073/25048 |