Substantial cell apoptosis provoked by naked PAMAM dendrimers in HER2-positive human breast cancer via JNK and ERK1/ERK2 signalling pathways

Substantial cell apoptosis provoked by naked PAMAM dendrimers in HER2-positive human breast cancer via JNK and ERK1/ERK2 signalling pathways

HER2-positive breast cancer is one of its most challenging subtypes, forming around 15–25% of the total cases. It is characterized by aggressive behavior and treatment resistance. On the other hand, poly (amidoamine) (PAMAM) dendrimers are widely used in drug delivery systems and gene transfection a...

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Bibliographic Details
Main Author: Hadeel, Kheraldine (author)
Other Authors: Gupta, Ishita (author), Alhussain, Hashim (author), Jabeen, Aayesha (author), Cyprian, Farhan S. (author), Akhtar, Saghir (author), Al Moustafa, Ala-Eddin (author), Rachid, Ousama (author)
Format: article
Published: 2021
Subjects:
PAMAMs
HER2-positive
Breast cancer
Chemoprevention
Apoptosis
Online Access:http://dx.doi.org/10.1016/j.csbj.2021.05.011
https://www.sciencedirect.com/science/article/pii/S2001037021001926
http://hdl.handle.net/10576/18454
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http://dx.doi.org/10.1016/j.csbj.2021.05.011
https://www.sciencedirect.com/science/article/pii/S2001037021001926
http://hdl.handle.net/10576/18454

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