Basophil-VAMP7 is a vital regulator of skin barrier integrity and chronic itch

Basophil-VAMP7 is a vital regulator of skin barrier integrity and chronic itch

BackgroundAtopic dermatitis (AD) is a multifaceted inflammatory skin disease characterized by chronic itch and acute itch flare (AIF), with basophils playing pivotal roles in both. VAMP7 mediates immune responses; however, its function in basophils remains undefined. ObjectiveWe sought to elucidate...

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Bibliographic Details
Main Author: Zhang, Wenhao (author)
Other Authors: Dai, Xiaolong (author), Chen, Weiwei (author), Li, Yanqing (author), Mei, Huiyuan (author), Buddenkotte, Jorg (author), Zhu, Xingyun (author), Steinhoff, Martin (author), Wang, Jiafu (author), Meng, Jianghui (author)
Format: article
Published: 2025
Subjects:
Atopic dermatitis
acute itch flare
inflammation
IL-4
LTC4
OSM
CCR3
CCL24
keratinocyte
macrophage
Online Access:http://dx.doi.org/10.1016/j.jaci.2025.02.035
https://www.sciencedirect.com/science/article/pii/S0091674925002726
http://hdl.handle.net/10576/65128
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http://dx.doi.org/10.1016/j.jaci.2025.02.035
https://www.sciencedirect.com/science/article/pii/S0091674925002726
http://hdl.handle.net/10576/65128

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