Novel thiazolones for the simultaneous modulation of PPARγ, COX-2 and 15-LOX to address metabolic disease-associated portal inflammation

Novel thiazolones for the simultaneous modulation of PPARγ, COX-2 and 15-LOX to address metabolic disease-associated portal inflammation

A hybrid pharmacophore model, based on structural motifs previously identified by our team, was employed to generate ligands that simultaneously target COX-2, 15-LOX, and PPARγ in the context of metabolic dysfunction-associated fatty liver disease (MAFLD). Notable COX-2 inhibitory activities (IC50 =...

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Bibliographic Details
Main Author: Mai S., El-Shoukrofy (author)
Other Authors: Ismail, Azza (author), Elhamammy, Reem H. (author), Abdelhady, Sherien A. (author), Nassra, Rasha (author), Makkar, Monica S. (author), Agami, Mahmoud A. (author), Wahid, Ahmed (author), Nematalla, Hisham A. (author), Sai, Minh (author), Merk, Daniel (author), El-Yazbi, Ahmed F. (author), Belal, Ahmed S.F. (author), Eid, Ali H. (author), Elzahhar, Perihan A. (author)
Format: article
Published: 2025
Subjects:
Thiazolones
PPARγ
COX-2
15-LOX
Multi-targeting
Liver inflammation
Metabolic diseases
Online Access:http://dx.doi.org/10.1016/j.ejmech.2025.117415
https://www.sciencedirect.com/science/article/pii/S0223523425001801
http://hdl.handle.net/10576/64011
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http://dx.doi.org/10.1016/j.ejmech.2025.117415
https://www.sciencedirect.com/science/article/pii/S0223523425001801
http://hdl.handle.net/10576/64011

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