A urokinase-activated recombinant diphtheria toxin targeting the granulocyte-macrophage colony-stimulating factor receptor is selectively cytotoxic to human acute myeloid leukemia blasts

A urokinase-activated recombinant diphtheria toxin targeting the granulocyte-macrophage colony-stimulating factor receptor is selectively cytotoxic to human acute myeloid leukemia blasts

Novel agents to treat acute myeloid leukemia (AML) are needed with increased efficacy and specificity. We have synthesized a dual-specificity fusion toxin DTU2GMCSF composed of the catalytic and translocation domains of diphtheria toxin (DT) fused to the granulocyte-macrophage colony-stimulating fac...

وصف كامل

محفوظ في:

التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Abi-Habib, Ralph J. (author)
مؤلفون آخرون:	Lui, Shihui (author), Bugge, Thomas (author), Leppla, Stephen H. (author), Frankel, Arthur (author)
التنسيق:	article
منشور في:	2004
الوصول للمادة أونلاين:	http://hdl.handle.net/10725/2732 http://dx.doi.org/10.1182/blood-2004-01-0339 http://www.bloodjournal.org/content/104/7/2143.full.pdf+html?sso-checked=true
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!

مواد مشابهة

Diphtheria toxin-murine granulocyte-macrophage colony-stimulating factor–induced hepatotoxicity is mediated by Kupffer cells
حسب: Abi-Habib, Ralph J.
منشور في: (2004)

A urokinase-activated recombinant anthrax toxin is selectively cytotoxic to many human tumor cell types
حسب: Abi-Habib, Ralph J.
منشور في: (2006)

Characterization of urokinase plasminogen activator-activated recombinant anthrax toxin for targeted cancer therapy
حسب: Abi-Habib, Ralph J.
منشور في: (2006)

Potency and selectivity of a urokinase activated recombinant anthrax toxin to acute myeloid leukemia (AML) cells. (c2015)
حسب: Darwich, Manal El.
منشور في: (2016)

Sensitivity of colorectal cancer cells to the recombinant Anthrax lethal toxin and the Urokinase-activated Anthrax lethal toxin. (c2014)
حسب: Kasbo, Zein Jean
منشور في: (2014)

Sensitivity of acute myeloid leukemia cells to the dual targeting of the urokinase plasminogen activator and the MAPK pathway by a urokinase-activated anthrax lethal toxin. (c2013)
حسب: Bekdash, Amira
منشور في: (2013)

Sensitivity of acute myeloid leukemia cell lines to the dual targeting of the urokinase system and the mapk pathway by modified anthrax toxins. (c2010)
حسب: Timsah, Zahra S.
منشور في: (2010)

Phospho-MEK1/2 and uPAR Expression Determine Sensitivity of AML Blasts to a Urokinase-Activated Anthrax Lethal Toxin (PrAgU2/LF) 1
حسب: Nasser, Selim
منشور في: (2015)

Cytotoxicity of Anthrax Lethal Toxin to Human Acute Myeloid Leukemia Cells Is Nonapoptotic and Dependent on Extracellular Signal-Regulated Kinase 1/2 Activity
حسب: Abi-Habib, Ralph J.
منشور في: (2013)

Increased Levels of Circulating and Tumor-Infiltrating Granulocytic Myeloid Cells in Colorectal Cancer Patients
حسب: Salman M. Toor (8854751)
منشور في: (2016)

Recombinant prostate-specific antigen proaerolysin shows selective protease sensitivity and cell cytotoxicity
حسب: Abi-Habib, Ralph
منشور في: (2007)

Myelomastocytic transformation in chronic myeloid leukemia blast phase: A case report
حسب: Abdulrahman F. Al-Mashdali (17148316)
منشور في: (2025)

Mechanisms of Cytotoxicity of Wild-Type Anthrax Lethal Toxin (PrAg/LF) to Acute Myeloid Leukemia Cells: The role of Autophagy
حسب: Sarout, Diamo
منشور في: (2024)

Targeting the MAP Kinase pathway in human acute myeloid leukemia cells using a recombinant anthrax lethal toxin. (c2013)
حسب: Kassab, Elias
منشور في: (2013)

The Effect of Recombinant Anthrax Lethal Toxin on Breast Cancer Cell Motility, Adhesion, and Invasion
حسب: El Chami, Dana
منشور في: (2020)

Human recombinant arginase I(Co)-PEG5000 [HuArgI(Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human acute myeloid leukemia cells
حسب: Bekdash, Amira
منشور في: (2013)

Characterization of the Cytotoxic Mechanism and Mode of Cell Death Induced by a MEK1/2-selective version of Anthrax Lethal Toxin (PrAg/LFW271A) in Acute Myeloid Leukemia
حسب: Mroue, Zeinab
منشور في: (2023)

The mechanisms of resistance of anthrax lethal toxin (LeTx)-induced cytotoxicity in AML cells. (c2018)
حسب: Abou Harb, Monica
منشور في: (2018)

Wild carrot oil extract is selectively cytotoxic to human acute myeloid leukemia cells
حسب: Tawil, Mirna
منشور في: (2015)

Tumor protease-activated fusion toxins
حسب: Abi-Habib, Ralph J.
منشور في: (2003)

Toll-like receptor stimulation of innate immunity triggers paradoxical suppression of CD8+ T-Cells
حسب: Abouantoun, T.
منشور في: (2010)

Rebar corrosion and sulfate resistance of blast-furnace slag cement
حسب: Saad, Ahmad
منشور في: (2020)

Targeting the MAP kinase pathway in astrocytoma cells using a recombinant anthrax lethal toxin as a way to inhibit cell motility and invasion
حسب: Al-Dimassi, Saleh
منشور في: (2016)

Regulative Loop between β-catenin and Protein Tyrosine Receptor Type γ in Chronic Myeloid Leukemia
حسب: Luisa Tomasello (702932)
منشور في: (2020)

Error performance of vertical-BLAST over Rayleigh and Nakagami fading channels
حسب: Khan, S.A.
منشور في: (2003)

Comparative Evaluation of Activated Carbon and Granulated Blast Furnace Slag in Treating Greywater
حسب: Iqbal, Fatima
منشور في: (2020)

Mechanisms of human recombinant arginase I (Co) - PEG5000 [Huarg I (Co) - PEG5000] - induced cytotoxicity on AML cells. (c2017)
حسب: Assaf, Nicole
منشور في: (2017)

Safety and efficacy of chimeric antigen receptor T-cell therapy for acute myeloid leukemia: A subgroup based meta-analysis
حسب: Mahmoud M. Morsy (18560491)
منشور في: (2024)

Predictive value of tyrosine phosphatase receptor gamma for the response to treatment tyrosine kinase inhibitors in chronic myeloid leukemia patients
حسب: Mohamed A. Ismail (418629)
منشور في: (2022)

Potential mechanisms of human recombinant arginase I (Co)-PEG5000 [HuArgI (CO) - PRG5000] induced cytotoxicity in glioblastoma cells. (c2018)
حسب: El Jawhari, Yassmine
منشور في: (2018)

Human recombinant arginase I (Co)-PEG5000 [HuArgI (Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human glioblastoma cells
حسب: Khoury, Oula
منشور في: (2015)

An investigation into the error performance of vertical-bell labs layered space-time architecture V-blast
حسب: Khan, Sajid Anwar
منشور في: (2003)

Dual Targeting of Matrix Metalloproteases and the MAPK Pathway in Acute Myeloid Leukemia Cells Using an MMP-activated anthrax lethal toxin (PrAgL1/LF)
حسب: Al Saneh, Ahmad
منشور في: (2020)

Systemic anthrax lethal toxin therapy produces regressions of subcutaneous human melanoma tumors in athymic nude mice
حسب: Abi-Habib, Ralph J.
منشور في: (2006)

Doxironide magnetic nanoparticles for selective drug delivery to human acute myeloid leukemia
حسب: Abi-Habib, Ralph
منشور في: (2017)

Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria
حسب: Jérémie Rosain (5900399)
منشور في: (2023)

French colonial trade patterns
حسب: El Kallab, Tania
منشور في: (2014)

Epigenetic regulation of immunosuppressive tumor-associated macrophages through dysregulated microRNAs
حسب: Aamir Ahmad (233201)
منشور في: (2022)

Bee Colony Algorithm for Proctors Assignment.
حسب: Mansour, Nashat
منشور في: (2015)

The Colonial impacts on French trade patterns
حسب: El Kallab, Tania
منشور في: (2017)

Cannot write session to /tmp/vufind_sessions/sess_41kba7lorhgq6no0e814d5l46c