Human recombinant arginase I(Co)-PEG5000 [HuArgI(Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human acute myeloid leukemia cells
In this study, we target arginine auxotrophy of AML cell lines using human arginase I cobalt-PEG5000. HuArgI(Co)-PEG5000 was cytotoxic to all AML cell lines tested. Mononuclear cells and CD34+ blasts were not sensitive demonstrating the selectivity of HuArgI(Co)-PEG5000-induced arginine deprivation....
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| Other Authors: | , , , , , |
| Format: | article |
| Published: |
2013
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| Online Access: | http://hdl.handle.net/10725/2741 http://dx.doi.org/10.1016/j.leukres.2013.08.007 http://www.sciencedirect.com/science/article/pii/S0145212613002889 |
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