Aspirin inhibition and recovery of cyclooxygenase activity and thromboxane biosynthesis in human megakaryocytes: a translational surrogate model
<p dir="ltr">Low-dose aspirin irreversibly acetylates cyclooxygenase (COX)-1 in anucleate platelets and progenitor megakaryocytes, permanently suppressing thromboxane (TX)A<sub>2</sub>-dependent platelet activation. Although aspirin pharmacodynamics is well characterized...
محفوظ في:
| المؤلف الرئيسي: | Zahraa I. Mallah (23125621) (author) |
|---|---|
| مؤلفون آخرون: | Giovanna Petrucci (268797) (author), Abeer J. Ayoub (9449147) (author), Mohammad A. Farhoud (23125624) (author), Joseph G. Jelwan (23125627) (author), Sara Lucchisani (23125630) (author), Adham K. Fakih (23125633) (author), Bassam Badran (215585) (author), Eva Hamade (584190) (author), Carlo Patrono (15106379) (author), Bianca Rocca (6330692) (author), Aida Habib (6686057) (author) |
| منشور في: |
2025
|
| الموضوعات: | |
| الوسوم: |
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