Azithromycin downregulates ICOS (CD278) and OX40 (CD134) expression and mTOR activity of TCR-activated T cells to inhibit proliferation

Azithromycin downregulates ICOS (CD278) and OX40 (CD134) expression and mTOR activity of TCR-activated T cells to inhibit proliferation

<p dir="ltr">The precise mechanism of macrolide antibiotic azithromycin (AZM) mediated CD4+ T cell suppression is not fully understood. Given the crucial role of co-stimulatory signaling in T-lymphocyte function, we tested in vitro effects of AZM on two of the most extensively invest...

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Bibliographic Details
Main Author: Abdul Wahid Ansari (9442697) (author)
Other Authors: Fareed Ahmad (134672) (author), Thesni Raheed (17017779) (author), Anh Jochebeth (17017782) (author), Jericha Miles Pamiloza Mateo (17017785) (author), Nabeel Abdulrahman (725914) (author), Elizabeth Febu Joy (17017788) (author), Majid Ali Alam (17017791) (author), Joerg Buddenkotte (6293584) (author), Rifat Akram Hamoudi (9442709) (author), Martin Steinhoff (5340194) (author)
Published: 2023
Subjects:
Biomedical and clinical sciences
Immunology
Pharmacology and pharmaceutical sciences
Azithromycin
T cells
ICOS
OX40
Proliferation
mTOR
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