ATM Inhibitors in Cancer Radiotherapy: Mechanisms, Clinical Development, and Future Directions
<p>Ataxia-telangiectasia mutated (ATM) kinase plays a pivotal role in the cellular response to DNA damage. Under normal conditions, ATM acts as a tumor suppressor by regulating pathways that lead to apoptosis and cell cycle arrest via effectors like p53, p21, CHK1, and CHK2. Paradoxically, in...
محفوظ في:
| المؤلف الرئيسي: | Raed.M. Al-Zoubi (22254577) (author) |
|---|---|
| مؤلفون آخرون: | Khalil Garada (22254580) (author), Reem Al Huneidi (22254583) (author), Zaid M.H. Baddar (22254586) (author), Ayman A. Zarour (17917709) (author), Mai Elaarag (17807390) (author), Sally R. Al-Zoubi (22254589) (author), Ahmad R. Al-Qudimat (17337808) (author), Mazhar Salim Al Zoubi (18024364) (author), Abdelali Agouni (181926) (author), Khalid Alrumaihi (14779210) (author) |
| منشور في: |
2025
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| الموضوعات: | |
| الوسوم: |
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